Partida-Hernández G, Arreola F, Fenton B, Cabeza M, Román-Ramos R, Revilla-Monsalve M C
Clinical and Experimental Diabetes Mellitus Laboratory, Faculty of Medical and Biological Sciences, Doctor-Ignacio-Chávez UMSNH, Morelia City, Mexico.
Biomed Pharmacother. 2006 May;60(4):161-8. doi: 10.1016/j.biopha.2006.02.004. Epub 2006 Mar 29.
Abnormal zinc and lipid plasma levels occur more frequently in metabolically uncontrolled diabetic patients. These lipid alterations are key factors in the emergence of microvascular complications, which lead to death in those patients. Yet, zinc sulfate supplementation may be a therapeutical resource to recover some functioning and improve life span. This article reports the assessment of lipid profile from type 2-diabetes mellitus patients treated with hypoglycemic therapy drugs, who additionally presented zinc levels lower than average in Mexican reference. The patients received a 100 mg zinc sulfate treatment in a crossover double-blind design of clinically controlled study with starch as placebo. The diabetic patients had changes in their lipid profile after a 12-week zinc treatment as compared with placebo treatment. The 100 mg zinc sulfate treatment was well tolerated, significantly reduced total cholesterol and triglyceride concentrations, and increased those corresponding to zinc as well as HDL cholesterol in the bloodstream. Thus, using this treatment the cardiovascular involvement is expected to decrease in the type 2-diabetes mellitus patients, especially those with myocardial infarction and stroke, which are the main death causes in Mexico.
在代谢未得到控制的糖尿病患者中，血浆锌和脂质水平异常更为常见。这些脂质改变是微血管并发症出现的关键因素，而微血管并发症会导致这些患者死亡。然而，补充硫酸锌可能是一种恢复某些功能并延长寿命的治疗手段。本文报告了对接受降糖治疗药物治疗的2型糖尿病患者脂质谱的评估，这些患者的锌水平低于墨西哥参考标准的平均水平。患者在一项以淀粉为安慰剂的临床对照研究的交叉双盲设计中接受了100毫克硫酸锌治疗。与安慰剂治疗相比，糖尿病患者在接受12周锌治疗后其脂质谱发生了变化。100毫克硫酸锌治疗耐受性良好，显著降低了总胆固醇和甘油三酯浓度，并提高了血液中锌以及高密度脂蛋白胆固醇的浓度。因此，使用这种治疗方法有望降低2型糖尿病患者的心血管受累情况，尤其是那些患有心肌梗死和中风的患者，而心肌梗死和中风是墨西哥主要的死亡原因。
