锌补充剂对 2 型糖尿病患者血脂谱的影响：随机临床试验的系统评价和剂量反应荟萃分析。
The Effect of Zinc Supplementation on Lipid Profiles in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Dose-Response Meta-Analysis of Randomized Clinical Trials.
机构信息
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Autoimmune Bullous Disease Research Center, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Adv Nutr. 2023 Nov;14(6):1374-1388. doi: 10.1016/j.advnut.2023.08.006. Epub 2023 Aug 19.
Research on the effects of zinc supplementation on lipid profiles in people with type 2 diabetes mellitus (T2DM) has been inconsistent. This systematic review and meta-analysis was performed to summarize the current data on the effects of zinc supplementation on lipid profiles in patients with T2DM. Three online databases including PubMed, Scopus, and Web of Science were searched to find relevant studies published until September 2022. The exposure was zinc supplementation, and the outcomes were low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG), and total cholesterol (TC). Fourteen randomized clinical trials consisting of 1067 patients were included in the statistical analysis. Significant improvement was observed in all 4 lipid profile components. Following zinc supplementation, a significant decrease was observed in TC (weighted mean difference [WMD]: -16.16; 95% confidence interval [CI]: -26.43, -5.89; P = 0.002), LDL (WMD: -6.18; 95% CI: -9.35, -3.02; P < 0.001), and TG (WMD: -13.08; 95% CI: -21.83, -4.34; P = 0.003). After analyzing 13 studies reporting HDL, a significant increase was seen (WMD: 3.76; 95% CI: 1.30, 6.22; P = 0.003). In a nonlinear dose-response analysis, a significant inverse association was observed between <12 wk zinc supplementation and TC, LDL, and TG (TC: WMD: -5, P < 0.001; LDL: WMD: -5, P = 0.07, TG: WMD: -16.5, P = 0.006). Nonlinear dose-response analysis shows that the optimum elemental zinc dosage for the best response to the supplementation for TC, LDL, and TG are 120, 100, and 140 mg/d, respectively (TC: WMD: -5, P < 0.001; LDL: WMD: -10, P = 0.006, TG: WMD: -50, P = 0.031). In conclusion, we found significant changes in all 4 components of the lipid profile through zinc supplementation in T2DM patients. Based on our findings, zinc supplementation may have profound favorable consequences on the lipid profile of T2DM patients, especially in the zinc-deficient group.
关于补充锌对 2 型糖尿病（T2DM）患者血脂谱影响的研究结果并不一致。本系统评价和荟萃分析旨在总结目前关于补充锌对 T2DM 患者血脂谱影响的研究数据。检索了 PubMed、Scopus 和 Web of Science 这 3 个在线数据库，以查找截至 2022 年 9 月发表的相关研究。暴露因素为锌补充剂，结局指标为低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、甘油三酯（TG）和总胆固醇（TC）。纳入了 14 项包含 1067 名患者的随机临床试验进行统计分析。所有 4 项血脂成分均观察到显著改善。补充锌后，TC（加权均数差 [WMD]：-16.16；95%置信区间 [CI]：-26.43，-5.89；P = 0.002）、LDL（WMD：-6.18；95% CI：-9.35，-3.02；P < 0.001）和 TG（WMD：-13.08；95% CI：-21.83，-4.34；P = 0.003）均显著降低。分析了 13 项报告 HDL 的研究，结果显示 HDL 显著增加（WMD：3.76；95% CI：1.30，6.22；P = 0.003）。在非线性剂量-反应分析中，锌补充 <12 周与 TC、LDL 和 TG 之间存在显著负相关（TC：WMD：-5，P < 0.001；LDL：WMD：-5，P = 0.07，TG：WMD：-16.5，P = 0.006）。非线性剂量-反应分析表明，补充锌对 TC、LDL 和 TG 的最佳反应的最佳元素锌剂量分别为 120、100 和 140 mg/d（TC：WMD：-5，P < 0.001；LDL：WMD：-10，P = 0.006，TG：WMD：-50，P = 0.031）。总之，我们发现补充锌后 T2DM 患者的血脂谱所有 4 项成分均有显著变化。根据我们的研究结果，锌补充可能对 T2DM 患者的血脂谱产生深远的有利影响，尤其是在缺锌组。
Zotero 插件