Zhang Q, van 't Hof M A, Truin G J, Bronkhorst E M, van Palenstein Helderman W H
Key Laboratory of Oral Biomedical Engineering (Wuhan University), Ministry of Education and Department of Endodontics, School and Hospital of Stomatology, PR China.
J Dent Res. 2006 May;85(5):469-72. doi: 10.1177/154405910608500514.
Evidence regarding the caries-inhibiting effect of chlorhexidine varnish is inconclusive. This study investigated the caries-inhibiting effect of the varnish EC40 on pits and fissures of first permanent molars. A two-year randomized controlled trial was carried out among 461 six- to seven-year-old children. In a split-mouth design, one group of molars received EC40 at baseline, 6, 12, and 18 months, and another group at baseline, 3, 12, and 15 months. Control molars did not receive EC40. Adherence to the treatment protocol was good. The dropout rate was 17%. Blinded examiners performed dental examinations. The caries-inhibiting effects of the two EC40 application schemes were comparable. The prevented fraction of caries was 25% (95%CI, 1%, 49%, p = 0.04) after 2 years and 9% (95%CI, -11%, 29%, p = 0.20) one year after termination of the trial, suggesting a short-term benefit from the use of EC40. The efficiency of EC40 is questionable in low-caries-incidence child populations.
关于洗必泰清漆防龋效果的证据尚无定论。本研究调查了清漆EC40对第一恒磨牙窝沟的防龋效果。对461名6至7岁儿童进行了一项为期两年的随机对照试验。采用半口设计，一组磨牙在基线、6个月、12个月和18个月时接受EC40，另一组在基线、3个月、12个月和15个月时接受EC40。对照磨牙未接受EC40。治疗方案的依从性良好。脱落率为17%。由盲法检查者进行牙科检查。两种EC40应用方案的防龋效果相当。试验结束2年后，龋齿预防率为25%（95%CI，1%，49%，p = 0.04），试验结束1年后为9%（95%CI，-11%，29%，p = 0.20），表明使用EC40有短期益处。在低龋齿发病率的儿童群体中，EC40的有效性值得怀疑。
