Pélissolo A, Huron C, Fanget F, Servant D, Stiti S, Richard-Berthe C, Boyer P
Service de Psychiatrie Adulte et CNRS UMR 7593, Hôpital Pitié-Salpêtrière (AP-HP), Paris, France.
Encephale. 2006 Jan-Feb;32(1 Pt 1):106-12. doi: 10.1016/s0013-7006(06)76143-7.
Only few clinical epidemiologic studies have been conducted on social phobia in France to date. It is however a frequent disorder, with often severe alteration of social adaptation and quality of life, and for which effective treatments exist. Thus, it seems really important to further explore how these patients are nowadays identified and treated in psychiatry. It was the objective of the Phoenix study. In this observational multi-center study, 952 psychiatric in- or out-patients, with a primary diagnosis of social phobia according to DSM IV criteria, were included. Numerous diagnostic and psychometric evaluations were carried out, in order to evaluate the comorbidity (Mini International Neuropsychiatric Interview, Hospital Anxiety and Depression Scale), the intensity of social anxiety (Liebowitz Social Anxiety Scale), and various aspects of the functional and emotional impact (Various Impact of Social Anxiety scale, Sheehan Disability Scale, SF-36, Positive and Negative Emotionality scale). The patients were in majority females (57.6%), with a mean age 37.5 years, and with a mean duration of social anxiety disorder 12.5 years. The mean scores of social anxiety on Liebowitz scale was 40.3 +/- 12.6 for the fear factor, and 38.3 +/- 13.6 for the avoidance factor. The generalized social anxiety subtype (anxiety in most social situations) was present in 67.8% of the patients. A major depressive disorder was found in 47.7% of the sample, and the prevalence of agoraphobia was even higher (49.2%). As known in clinical practice and in other studies, the prevalence rates of current alcohol dependence and substances abuse were also important in this population (respectively 10.6% and 12.7%). Mean scores of the Hospital Anxiety and Depression (HAD) sub-scales were 13.9 +/-3.8 for anxiety and 9.1 +/-4.5 for depression. About 15% of the patients had a history of suicide attempt, and a suicidal risk was present in nearly 40% of the sample. The psychosocial impact and the alteration of quality of life (with especially a poor physical health perception) were very significant, in the family, educational or occupational and social domains. Mean scores of the Sheehan Disability Scale were 6.1 +/- 2.6 for professional impairment, 5.0 +/- 2.7 for familial impairment, and 6.6 +/- 2.3 for social life impairment. In addition to the disability due to social phobia intensity, an important part of the burden was due to depressive symptoms. Approximately 60% of the patients had already a psychiatric treatment at the time of the survey (since 1,7 years in average), but only 17% had a cognitive behavioral therapy (CBT), and 48% had an antidepressant treatment. These proportions increased in a significant way after the consultation during which the investigation was carried out: an antidepressant was prescribed to 72% of the patients, and a CBT is proposed to 48%. On the whole, this study confirmed the severity and the morbidity of social phobia in a very large sample of French psychiatric patients. The depressive disorders, suicidal risk, and social impairment associated with this condition should incite to more detect and treat it. Seeing the long duration of the disease in our sample, and the lack of specific therapies in many cases, the identification and the treatment of social phobia must be improved, and the role of the psychiatrists in this process seems very important.
迄今为止,法国仅开展了少量关于社交恐惧症的临床流行病学研究。然而,社交恐惧症是一种常见疾病,常常严重影响社交适应能力和生活质量,且有有效的治疗方法。因此,进一步探究如今精神科如何识别和治疗这些患者显得尤为重要。这就是“凤凰研究”的目的。在这项多中心观察性研究中,纳入了952例根据《精神疾病诊断与统计手册》第四版标准初步诊断为社交恐惧症的精神科门诊或住院患者。进行了多项诊断和心理测评,以评估共病情况(迷你国际神经精神访谈、医院焦虑抑郁量表)、社交焦虑强度(利博维茨社交焦虑量表)以及功能和情感影响的各个方面(社交焦虑的各种影响量表、希恩残疾量表、SF - 36、正负情绪量表)。患者以女性居多(57.6%),平均年龄37.5岁,社交焦虑障碍平均病程12.5年。利博维茨量表上社交焦虑的平均得分,恐惧因子为40.3±12.6,回避因子为38.3±13.6。广泛性社交焦虑亚型(在大多数社交场合感到焦虑)在67.8%的患者中存在。47.7%的样本存在重度抑郁症,广场恐惧症的患病率更高(49.2%)。正如临床实践和其他研究中所知,该人群中当前酒精依赖和药物滥用的患病率也较高(分别为10.6%和12.7%)。医院焦虑抑郁量表各分量表的平均得分,焦虑为13.9±3.8,抑郁为9.1±4.5。约15%的患者有自杀未遂史,近40%的样本存在自杀风险。心理社会影响和生活质量改变(尤其是对身体健康的认知较差)在家庭、教育、职业和社交领域都非常显著。希恩残疾量表的平均得分,职业损害为6.1±2.6,家庭损害为5.0±2.7,社交生活损害为6.6±2.3。除了社交恐惧症强度导致的残疾外,很大一部分负担归因于抑郁症状。约60%的患者在调查时已经接受过精神科治疗(平均1.7年),但只有17%接受过认知行为疗法(CBT),48%接受过抗抑郁治疗。在进行调查的会诊后,这些比例显著增加:72%的患者被开了抗抑郁药,48%的患者被建议接受CBT。总体而言,这项研究证实了社交恐惧症在大量法国精神科患者样本中的严重性和发病率。与这种疾病相关的抑郁症、自杀风险和社交障碍应促使人们更多地去发现和治疗它。鉴于我们样本中疾病病程较长,且在许多情况下缺乏特定疗法,社交恐惧症的识别和治疗必须得到改善,精神科医生在这一过程中的作用似乎非常重要。