Ettorre Giuseppe Maria, Douard Richard, Santoro Roberto, Vidiri Antonello, Vennarecci Giovanni, Carboni Fabio, Boschetto Arianna, Corazza Valerio, Maritti Michela, Antonini Mario, Santoro Eugenio
Service de Chirurgie Digestive et de Transplantation Hépatique, Institut de cancérologie Regina Elena, Rome, Italie.
Gastroenterol Clin Biol. 2006 Mar;30(3):476-9. doi: 10.1016/s0399-8320(06)73207-9.
Intralesional massive haemorrhage responsible for inferior vena cava syndrome is a very rare complication of hepatocellular carcinoma. A 36-year-old man with no past medical history was referred to hospital for abdominal pain with clinical and biological signs of internal bleeding. An abdominal CT scan showed a huge right liver mass, with regular margins and a fluid content, indicating a large intratumoral haemorrhage complicating hepatocellular carcinoma. Due to haemodynamic stability and the signs of inferior vena cava compression conservative management was chosen prior to surgical treatment of the tumour. Three months later, the huge liver mass remained unchanged but the inferior vena cava syndrome had decreased and the patient's condition improved. After evaluation of liver function and the extent of the tumour, a surgical procedure was performed via a subcostal incision with midline extension and sternotomy to control the intrapericardial inferior vena cava and perform a veno-venous bypass with the technique used for orthotopic liver transplantation. Then, right hepatectomy (segments V to VIII) was performed with an anterior approach. The postoperative course was uneventful. This two-step strategy allowed successful surgery for this rare complication of a hepatocellular carcinoma on a normal liver and could be recommended for the management of any unruptured intratumoral haemorrhages.
导致下腔静脉综合征的瘤内大量出血是肝细胞癌非常罕见的并发症。一名无既往病史的36岁男性因腹痛伴内出血的临床和生物学体征被转诊至医院。腹部CT扫描显示肝脏右叶有一个巨大肿块,边缘规则,有液性成分,提示巨大瘤内出血并发肝细胞癌。由于血流动力学稳定且存在下腔静脉受压体征,在对肿瘤进行手术治疗之前选择了保守治疗。三个月后,巨大肝脏肿块大小未变,但下腔静脉综合征有所减轻,患者病情好转。在评估肝功能和肿瘤范围后,通过肋下切口加中线延长和胸骨切开术进行手术,以控制心包内下腔静脉并采用原位肝移植技术进行静脉-静脉旁路手术。然后,采用前路进行右肝切除术(V至VIII段)。术后过程顺利。这种两步策略使对正常肝脏上肝细胞癌这种罕见并发症的手术得以成功进行,可推荐用于处理任何未破裂的瘤内出血。