Eksioglu Emel, Tuncay Reyhan, Gurcay Eda, Bal Ajda, Cakci Aytul
Department of Physical Therapy and Rehabilitation, Ministry of Health Ankara Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.
Clin Rheumatol. 2007 Mar;26(3):314-8. doi: 10.1007/s10067-006-0293-3. Epub 2006 Apr 22.
This study aims to examine the long-term articular damage in rheumatoid arthritis (RA) patients according to rheumatoid arthritis articular damage (RAAD) score and to evaluate the parameters correlated with this score. The RAAD score was assessed in 85 RA patients who had the disease for more than 10 years. Patients were divided into three groups according to duration of the disease: group 1, 10-14 years; group 2, 15-19 years; and group 3, more than 20 years. Patients were also divided into three groups according to the time of initiation of treatment with disease-modifying antirheumatic drugs: group A, within the first 2 years, group B, between 2 and 5 years; and group C, after 5 years. We investigated the RAAD score relationship between groups 1, 2, 3; groups A, B, C; sex; drug compliance; age of onset of the disease; and Health Assessment Questionnaire (HAQ). We observed significant differences in RAAD scores according to groups 1, 2, 3 (p<0.01), but not to groups A, B, C; sex; or drug compliance (p>0.05). While the RAAD score correlated well with the HAQ (r=0.560, p<0.001), it did not correlate with the age at onset of the disease (p>0.05). As RA is not a benign disease and articular damage progresses over time, the goal of RA therapy must be to maintain a response before the onset of irreversible damage and loss of function.
本研究旨在根据类风湿关节炎关节损伤（RAAD）评分，研究类风湿关节炎（RA）患者的长期关节损伤情况，并评估与该评分相关的参数。对85例患RA超过10年的患者进行了RAAD评分评估。根据病程将患者分为三组：第1组，病程10 - 14年；第2组，病程15 - 19年；第3组，病程超过20年。患者还根据使用改善病情抗风湿药物的起始时间分为三组：A组，在发病的前2年内；B组，在发病2至5年之间；C组，在发病5年后。我们研究了第1、2、3组之间；A、B、C组之间；性别；药物依从性；发病年龄；以及健康评估问卷（HAQ）与RAAD评分的关系。我们观察到，根据第1、2、3组划分，RAAD评分存在显著差异（p<0.01），但根据A、B、C组划分、性别或药物依从性划分则无显著差异（p>0.05）。虽然RAAD评分与HAQ相关性良好（r = 0.560，p<0.001），但与发病年龄无相关性（p>0.05）。由于RA并非良性疾病，且关节损伤会随时间进展，RA治疗的目标必须是在不可逆转的损伤和功能丧失发生之前维持疗效。
