Akkuş Aşkin, Gülmen Mustafa, Cevik Ayhan, Bildik Nejdet, Sad Orhan, Oztürk Erdem, Barişik Nagihan Ozdemir
Second Surgery Clinic, Dr. Lütfi Kirdar Education and Research Hospital, Kartal, 34865, Istanbul, Turkey.
Surg Today. 2006;36(5):436-40. doi: 10.1007/s00595-005-3155-8.
The reported antibacterial, antiendotoxic, and antiadhesive effects of taurolidine prompted us to study the benefits of intraperitoneal lavage with taurolidine on primary colonic anastomosis in a rat model of secondary peritonitis.
We induced peritonitis in 40 rats by injecting Escherichia coli isolate intraperitoneally. We performed colonic resection and primary anastomosis 5 h later, after lavage with either taurolidine or saline solution. After the rats were killed, on postoperative day (POD) 3 (n = 10) or 7 (n = 10), we measured the bursting pressures and hydroxyproline levels, then examined the resected specimens histologically.
Bursting pressures and tissue hydroxyproline levels were significantly higher in the taurolidine group than in the control group on PODs 3 and 7 (P < 0.05). Histopathological examination revealed significantly higher fibroblastic activity in the taurolidine group.
The higher bursting pressures and tissue hydroxyproline levels in the rats given taurolidine showed the positive effect of taurolidine on anastomotic strength in secondary peritonitis. Taurolidine is a novel antibiotic with both antibacterial and antiendotoxic effects. Intraperitoneal lavage with taurolidine solution may reduce the risks associated with performing primary colonic anastomosis in patients with secondary peritonitis.
已报道的牛磺罗定的抗菌、抗内毒素和抗黏附作用促使我们在继发性腹膜炎大鼠模型中研究腹腔内灌注牛磺罗定对原发性结肠吻合术的益处。
我们通过腹腔注射大肠杆菌分离株在40只大鼠中诱发腹膜炎。5小时后，在用牛磺罗定或盐溶液灌洗后，我们进行结肠切除术和原发性吻合术。大鼠处死后，在术后第3天（n = 10）或第7天（n = 10），我们测量破裂压力和羟脯氨酸水平，然后对切除的标本进行组织学检查。
在术后第3天和第7天，牛磺罗定组的破裂压力和组织羟脯氨酸水平显著高于对照组（P < 0.05）。组织病理学检查显示牛磺罗定组的成纤维细胞活性显著更高。
给予牛磺罗定的大鼠中更高的破裂压力和组织羟脯氨酸水平表明牛磺罗定对继发性腹膜炎中吻合强度有积极作用。牛磺罗定是一种具有抗菌和抗内毒素作用的新型抗生素。腹腔内灌注牛磺罗定溶液可能会降低继发性腹膜炎患者进行原发性结肠吻合术的相关风险。
