Yamashita Kazunori, Fukusaki Makoto, Ando Yuko, Fujinaga Arihiro, Tanabe Takahiro, Terao Yoshiaki, Sumikawa Koji
Department of Anesthesia, Nagasaki Rosai Hospital, 2-12-5 Setogoshi, Sasebo 857-0134, Japan.
J Anesth. 2006;20(2):92-5. doi: 10.1007/s00540-006-0389-6.
The aim of the study was to investigate postoperative analgesia and the opioid-sparing effect of the preoperative administration of intravenous flurbiprofen axetil in patients undergoing spinal fusion surgery.
Thirty-six patients were randomly allocated into one of three groups. Group A received preoperative flurbiprofen axetil, 1 mg x kg(-1). Group B received postoperative flurbiprofen axetil, 1 mg x kg(-1). Group C received a placebo. All groups were given a standardized anesthesia and intravenous morphine via a patient-controlled analgesia device for postoperative analgesia. The pain score was evaluated by a visual analog scale (VAS) at 0 (T(0)), 1 (T(1)), 2 (T(2)), 6 (T(3)), 12 (T(4)), and 24 (T(5)) h after surgery, and the morphine requirement was recorded during the study period.
VAS in group A was significantly lower than that in group B at T(0) and T(1). VAS in group A was significantly lower than that in group C throughout the time course after surgery. Postoperative morphine consumption in group A was significantly lower than that in groups B and C at T(0) to T(3).
As compared with postoperative administration, preoperative administration of intravenous flurbiprofen axetil provides better postoperative analgesia and an opioid-sparing effect in patients undergoing spinal fusion surgery under general anesthesia.
本研究旨在探讨在接受脊柱融合手术的患者中，术前静脉注射氟比洛芬酯的术后镇痛效果及阿片类药物节省效应。
36例患者被随机分为三组。A组术前接受1mg/kg氟比洛芬酯。B组术后接受1mg/kg氟比洛芬酯。C组接受安慰剂。所有组均给予标准化麻醉，并通过患者自控镇痛装置静脉注射吗啡用于术后镇痛。术后0（T0）、1（T1）、2（T2）、6（T3）、12（T4）和24（T5）小时采用视觉模拟评分法（VAS）评估疼痛评分，并记录研究期间的吗啡需求量。
在T0和T1时，A组的VAS显著低于B组。术后整个时间段内，A组的VAS显著低于C组。在T0至T3时，A组术后吗啡消耗量显著低于B组和C组。
与术后给药相比，术前静脉注射氟比洛芬酯在全身麻醉下接受脊柱融合手术的患者中提供了更好的术后镇痛效果及阿片类药物节省效应。
