Ma Xing-Dui, Li Bei-Ping, Wang De-Ling, Yang Wen-Sheng
Department of Anesthesiology, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu 221002, P.R. China.
Exp Ther Med. 2017 Sep;14(3):2148-2152. doi: 10.3892/etm.2017.4717. Epub 2017 Jul 4.
The present study determined the effect of dexmedetomidine (Dex) combined with flurbiprofen axetil (FA) on analgesia, immune response, and preservation of cognitive function in patients subjected to general anesthesia. We recruited 100 patients with thyroid surgery and randomly divided them into four groups: Dex (D), FA (F), Dex combined with FA (DF), and saline control (C). The extubation and recovery times for Groups D and DF were significantly longer than for Groups F and C. After extubation, the heart rate and mean arterial pressure for Groups F, D, and DF were significantly lower than for Group C, and data for Group DF was significantly lower than for Group F. The visual analog scale and Riker sedation agitation scores were significantly lower in Group DF than for the other three groups. T- and B-lymphocytes were significantly higher in Group DF than in the other three groups. Compared with Groups F and C, the levels of TNF-α and IL-6 in Group DF were significantly reduced, while IL-2 markedly increased. The combined use of Dex and FA significantly improved pain after general anesthesia thyroid surgery, reduced restlessness and postoperative cognitive dysfunction, enhanced immune function, and promoted wound repair.
本研究确定了右美托咪定（Dex）联合氟比洛芬酯（FA）对全身麻醉患者镇痛、免疫反应及认知功能保护的影响。我们招募了100例甲状腺手术患者，并将他们随机分为四组：右美托咪定组（D组）、氟比洛芬酯组（F组）、右美托咪定联合氟比洛芬酯组（DF组）和生理盐水对照组（C组）。D组和DF组的拔管和恢复时间显著长于F组和C组。拔管后，F组、D组和DF组的心率和平均动脉压显著低于C组，且DF组的数据显著低于F组。DF组的视觉模拟评分和Riker镇静躁动评分显著低于其他三组。DF组的T淋巴细胞和B淋巴细胞显著高于其他三组。与F组和C组相比，DF组的TNF-α和IL-6水平显著降低，而IL-2显著升高。右美托咪定与氟比洛芬酯联合使用显著改善了全身麻醉甲状腺手术后的疼痛，减少了躁动和术后认知功能障碍，增强了免疫功能，并促进了伤口修复。
