Moreno Ramíez Everardo, Hernández Urzúa Miguel Angel, González Villegas Ana Cecilia, Casas Solís Josefina, Zaitseva Galina
Pasantes de Doctorado en Inmunología, Universidad de Guadalajara.
Rev Alerg Mex. 2006 Jan-Feb;53(1):3-8.
Urban environmental pollutants, resulting from the inadequate control in the industries and from the use of vehicles, still represent a great danger for millions of people all around the world.
We made a study in healthy young people without family history of atopy that lived in Guadalajara's downtown, as well as in another group of young people who lived in a rural area. According to the census of the year 2000, Guadalajara city has a population of 4 million habitants, and a vehicle number of about a million. The immunological parameters that we studied were: IgG, IgA and IgM immunoglobulins by nephelometry, serum levels of proinflammatory cytokines IL-6, IL-1alpha, IL1-beta and TNF-alpha by ELISAs test, and the phagocytic index in polymorphonuclears. The atmospheric parameters were: NO2, O3, SO2, CO and the suspended particles that were less than 10 micrometers (PM10). These parameters were obtained from a mobile unit found at the Instituto de Astronomia y Meteorología de la Universidad de Guadalajara, and from an automatic station of environmental monitoring.
It stands out the high concentrations of NO2 and PM10, which in several occasions were over the standards established by the WHO. IgG, IgA and IgM immunoglobulins were lower in the subjects living in the city that in those who lived in the rural area. Phagocytic index in polymorphonuclears, as well as IL-1alpha levels were higher in the city group, though we did not find a significant difference in the immunological parameters analyzed in the studied groups.
Environmental pollution levels found at Guadalajara's downtown does not modify the immunological parameters studied in the peripheral blood of healthy young people. This shows that this group of population is less vulnerable than others to the exposition of moderate levels of urban air pollution.
工业管控不力和车辆使用导致的城市环境污染物，对全球数百万人仍构成巨大威胁。
我们对居住在瓜达拉哈拉市中心且无特应性家族史的健康年轻人，以及另一组居住在农村地区的年轻人进行了研究。根据2000年的人口普查，瓜达拉哈拉市有400万居民，车辆数量约为100万辆。我们研究的免疫参数包括：通过散射比浊法检测的IgG、IgA和IgM免疫球蛋白，通过酶联免疫吸附测定法检测的促炎细胞因子IL-6、IL-1α、IL-1β和TNF-α的血清水平，以及多形核细胞的吞噬指数。大气参数包括：二氧化氮、臭氧、二氧化硫、一氧化碳以及小于10微米的悬浮颗粒物（PM10）。这些参数来自瓜达拉哈拉大学天文与气象研究所的一个移动装置，以及一个环境监测自动站。
二氧化氮和PM10的高浓度尤为突出，在某些情况下超过了世界卫生组织制定的标准。居住在城市的受试者体内的IgG、IgA和IgM免疫球蛋白低于居住在农村地区的受试者。城市组的多形核细胞吞噬指数以及IL-1α水平较高，不过我们在所研究的组中分析的免疫参数未发现显著差异。
在瓜达拉哈拉市中心发现的环境污染水平并未改变健康年轻人外周血中所研究的免疫参数。这表明该人群对中等程度的城市空气污染暴露的易感性低于其他人群。
