HLA Cw*06对于链球菌诱导的银屑病并非必不可少。

HLA Cw*06 is not essential for streptococcal-induced psoriasis.

作者信息

Fry L, Powles A V, Corcoran S, Rogers S, Ward J, Unsworth D J

机构信息

Faculty of Medicine, Imperial College, London, UK, and The Skin Hospital, Dublin 2, Ireland.

出版信息

Br J Dermatol. 2006 May;154(5):850-3. doi: 10.1111/j.1365-2133.2005.07101.x.

DOI:10.1111/j.1365-2133.2005.07101.x

PMID:16634885

Abstract

BACKGROUND

Streptococcal throat infections and HLA Cw6 (Cw*06) have been implicated in the pathogenesis of psoriasis, particularly in the guttate form.

OBJECTIVES

To study 105 Irish patients with psoriasis to investigate the relationship between streptococcal infections and Cw*06.

METHODS

The patients were divided into two groups: those with guttate psoriasis or guttate flare (guttate group, GG, n=64) and those with chronic plaque psoriasis (chronic plaque group, CPG, n=41).

RESULTS

The incidence of Cw06 was 86% in the GG and 73% in the CPG, which was not significantly different (P=0.1725) but the incidence in both groups was significantly higher than in an Irish control group (18%) (P<0.0001 vs. GG and P<0.0001 vs. CPG). Evidence for streptococcal infection was higher in the GG (56%) than in the CPG (32%) (P=0.0231). Of those patients with evidence of streptococcal infection, 30 of 36 GG (83%) and nine of 13 CPG (69%) patients possessed the Cw06 genotype.

CONCLUSIONS

Thus, not all patients with streptococcal-related psoriasis carry Cw06. The role of Cw06 in psoriasis, if any, has yet to be determined.

摘要

背景

链球菌性咽喉感染和HLA Cw6（Cw*06）与银屑病的发病机制有关，尤其是点滴状银屑病。

目的

研究105例爱尔兰银屑病患者，以探讨链球菌感染与Cw*06之间的关系。

方法

将患者分为两组：点滴状银屑病或点滴状皮疹发作患者（点滴状组，GG，n = 64）和慢性斑块状银屑病患者（慢性斑块状组，CPG，n = 41）。

结果

Cw06在GG组中的发生率为86%，在CPG组中为73%，差异无统计学意义（P = 0.1725），但两组的发生率均显著高于爱尔兰对照组（18%）（与GG组相比P < 0.0001，与CPG组相比P < 0.0001）。GG组（56%）链球菌感染的证据高于CPG组（32%）（P = 0.0231）。在有链球菌感染证据的患者中，36例GG组患者中有30例（83%）和13例CPG组患者中有9例（69%）具有Cw06基因型。