Prinz J C
Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, Frauenlobstrasse 9-11, Munich, Germany.
Hautarzt. 2009 Feb;60(2):109-15. doi: 10.1007/s00105-008-1661-5.
Infections with Streptococcus pyogenes are highly relevant among the environmental factors that contribute to first onset or relapses of psoriasis in predisposed individuals. Streptococcal angina or pharyngitis, but also perianal streptococcal dermatitis, vulvovaginitis or balanoposthitis are potential causes. Several mechanisms such as molecular mimicry or superantigens may be involved. Many patients develop a chronic streptococcal infection or colonization that may result from the ability of streptococci for intracellular uptake and persistence in epithelial cells. Whether and under what conditions a curative treatment of streptococcal infection by tonsillectomy or antibiotic treatment may affect the course of psoriasis, as proposed by several observations, needs to be determined in more detail by clinical trials.
在导致易感个体银屑病初发或复发的环境因素中，化脓性链球菌感染高度相关。链球菌性心绞痛或咽炎，以及肛周链球菌性皮炎、外阴阴道炎或阴茎头炎都是潜在病因。可能涉及分子模拟或超抗原等多种机制。许多患者会出现慢性链球菌感染或定植，这可能源于链球菌摄取并持续存在于上皮细胞内的能力。扁桃体切除术或抗生素治疗对链球菌感染的根治性治疗是否以及在何种情况下会影响银屑病病程，正如一些观察结果所提出的那样，需要通过临床试验更详细地确定。
