波兰北部70例点滴状银屑病患者的链球菌上呼吸道感染频率及HLA - Cw*06等位基因情况

Frequency of streptococcal upper respiratory tract infections and HLA-Cw*06 allele in 70 patients with guttate psoriasis from northern Poland.

作者信息

Maciejewska-Radomska Agata, Szczerkowska-Dobosz Aneta, Rębała Krzysztof, Wysocka Joanna, Roszkiewicz Jadwiga, Szczerkowska Zofia, Placek Waldemar

机构信息

Department of Dermatology, Venereology and Clinical Immunology, University of Warmia and Mazury, Olsztyn, Poland Head of the Department: Prof. Waldemar Placek MD, PhD.

Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland Head of the Department: Prof. Roman Nowicki MD, PhD.

出版信息

Postepy Dermatol Alergol. 2015 Dec;32(6):455-8. doi: 10.5114/pdia.2014.40982. Epub 2015 Dec 11.

DOI:10.5114/pdia.2014.40982

PMID:26755910

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4697014/

Abstract

INTRODUCTION

The association of guttate psoriasis with a streptococcal throat infection and HLA-Cw*06 allele is well established in different populations. Nevertheless, only few studies on this form of disease have been performed in the Polish population.

AIM

To analyze the frequencies of streptococcal-induced guttate psoriasis and HLA-Cw*06 allele in 70 patients with guttate psoriasis originating from northern Poland.

MATERIAL AND METHODS

Seventy patients with guttate psoriasis and 24 healthy volunteers were enrolled into the study. Both groups were sex- and age-matched. The evidence of streptococcal infection was based on the positive throat swabs and/or elevated ASO titers. The modified method, including PCR-SSP and PCR-RFLP, was applied to HLA-Cw*06 genotyping.

RESULTS

HLA-Cw06 allele was confirmed in 49 (70%) out of 70 patients, which is significantly higher than in the control population (30%) (p = 0.001). Evidence for streptococcal infection was found in 34 (48.5%) subjects with psoriasis. Twenty-seven of them (79%) carried HLA-Cw06 allele. In 36 individuals in whom no evidence of streptococcal infection was found, 14 (39%) did not carry HLA-Cw*06 allele.

CONCLUSIONS

Our data confirm that HLA-Cw*06 is a major, but not imperative, genetic determinant for guttate psoriasis.

摘要

引言

点滴状银屑病与链球菌性咽炎感染及HLA - Cw*06等位基因之间的关联在不同人群中已得到充分证实。然而，针对波兰人群中这种疾病形式的研究却很少。

目的

分析来自波兰北部的70例点滴状银屑病患者中链球菌诱发的点滴状银屑病及HLA - Cw*06等位基因的频率。

材料与方法

70例点滴状银屑病患者和24名健康志愿者纳入本研究。两组在性别和年龄上匹配。链球菌感染的证据基于咽拭子阳性和/或抗链球菌溶血素O滴度升高。采用改良方法，包括聚合酶链反应-序列特异性引物法（PCR - SSP）和聚合酶链反应-限制性片段长度多态性法（PCR - RFLP）对HLA - Cw*06进行基因分型。

结果

70例患者中有49例（70%）检测到HLA - Cw06等位基因，这显著高于对照组人群（30%）（p = 0.001）。在34例（48.5%）银屑病患者中发现有链球菌感染证据。其中27例（79%）携带HLA - Cw06等位基因。在36例未发现链球菌感染证据的个体中，14例（39%）未携带HLA - Cw*06等位基因。