Ogawa Hiroshi, Yoshihara Akihiro, Amarasena Najith, Hirotomi Toshinobu, Miyazaki Hideo
Division of Preventive Dentistry, Department of Oral Health Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
J Clin Periodontol. 2006 May;33(5):312-6. doi: 10.1111/j.1600-051X.2005.00901.x.
The purpose of this study was to evaluate the relationship between periodontal disease and general health status in community-dwelling elderly using serum albumin concentration as a criterion index of the severity of an underlying disease and nutrition status.
Serum albumin level was detected by the bromcresol green albumin (BCG) method and the data for serum albumin were available in 368 subjects aged 75 years. Pressure-sensitive probes were used to measure loss of attachment (LA) on six sites of all teeth present. Information relevant to gender and smoking habit was obtained by means of a personal interview, while body mass index (BMI) and biochemical serum markers were investigated.
Serum albumin concentration ranged from 3.2 to 4.8 g/dl with a mean of 4.1+/-0.2. More than 70% of subjects had at least one site with LA 6+ mm, while 91 exhibited 10% or more sites with LA 6+ mm. Using a multiple regression analysis, we found that sites of LA 6+ mm had a significant effect on serum albumin level (correlation coefficient=-0.14; p<0.05), which was independent of the other covariates.
The findings of the present study indicated that there might be an inverse relationship between periodontal disease and serum albumin concentration in these elderly subjects.
本研究旨在以血清白蛋白浓度作为潜在疾病严重程度和营养状况的标准指标，评估社区居住老年人牙周疾病与总体健康状况之间的关系。
采用溴甲酚绿白蛋白（BCG）法检测血清白蛋白水平，368名75岁受试者有血清白蛋白数据。使用压敏探针测量所有现存牙齿六个部位的附着丧失（LA）。通过个人访谈获取性别和吸烟习惯相关信息，同时调查体重指数（BMI）和生化血清标志物。
血清白蛋白浓度范围为3.2至4.8 g/dl，平均值为4.1±0.2。超过70%的受试者至少有一个部位的LA为6+mm，而91名受试者有10%或更多部位的LA为6+mm。通过多元回归分析，我们发现LA为6+mm的部位对血清白蛋白水平有显著影响（相关系数=-0.14；p<0.05），且独立于其他协变量。
本研究结果表明，在这些老年受试者中，牙周疾病与血清白蛋白浓度之间可能存在负相关关系。
