Iwasaki Masanori, Yoshihara Akihiro, Hirotomi Toshinobu, Ogawa Hiroshi, Hanada Nobuhiro, Miyazaki Hideo
Department of Oral Health Science, Division of Preventive Dentistry, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
J Clin Periodontol. 2008 Apr;35(4):291-6. doi: 10.1111/j.1600-051X.2008.01215.x.
The purpose of this study was to evaluate the relationship between periodontal disease and the general health status in community-dwelling elderly using the serum albumin concentration as a criterion index of the severity of underlying disease and nutrition.
Six hundred subjects aged 70 years underwent a baseline examination. Dental examinations were carried out at baseline and once a year for 4 years. Periodontal conditions were estimated for subjects with at least one remaining tooth. Clinical attachment levels at six sites of all teeth present were measured. A change in loss of attachment of 3 mm or greater in 1 year at each site was defined as periodontal disease progression. Data were analysed in subjects for whom data were available for 4 years.
Serum albumin concentration at baseline ranged from 3.4 to 5.0 g/dl with a mean of 4.3+/-0.2. When the analysis was stratified by smoking status, we found that serum albumin concentration had a significant effect on periodontal disease progression among non-smokers (standardized regression coefficient=-0.16; p=0.017), using multiple regression analysis.
The findings of the present study suggest that serum albumin concentration is a significant risk predictor of periodontal disease progression among elderly non-smokers.
本研究旨在以血清白蛋白浓度作为潜在疾病严重程度和营养状况的标准指标，评估社区居住老年人牙周疾病与总体健康状况之间的关系。
600名70岁的受试者接受了基线检查。在基线时以及之后4年每年进行一次牙科检查。对至少保留一颗牙齿的受试者评估牙周状况。测量所有现存牙齿六个部位的临床附着水平。每个部位一年内附着丧失增加3毫米或更多被定义为牙周疾病进展。对有4年可用数据的受试者进行数据分析。
基线时血清白蛋白浓度范围为3.4至5.0克/分升，平均为4.3±0.2。当按吸烟状况分层分析时，我们发现使用多元回归分析，血清白蛋白浓度对非吸烟者的牙周疾病进展有显著影响（标准化回归系数=-0.16；p=0.017）。
本研究结果表明，血清白蛋白浓度是老年非吸烟者牙周疾病进展的重要风险预测指标。
