Bernstein Charles N, Walker John R, Graff Lesley A
Am J Gastroenterol. 2006 Apr;101(4):782-5. doi: 10.1111/j.1572-0241.2006.00474.x.
A number of investigators over the years have attempted to determine if a relationship exists between flares of inflammatory bowel disease (IBD) and stress. There are many complexities to addressing this issue, including determining the appropriate tools to measure stress, determining the appropriate measures of quantifying a disease flare and also determining the point at which the timing of the stress could be seen to be reasonably related to the onset of the flare. While advances have been made in understanding physiological responses to acute stress, it is unclear whether it is acute, chronic, or recurrent stress that might most impact on a chronic inflammatory disease. In the case of IBD, the disease itself poses a stress to the individual further clouding the issue.
多年来，许多研究人员试图确定炎症性肠病（IBD）的发作与压力之间是否存在关联。解决这个问题存在许多复杂因素，包括确定测量压力的合适工具、确定量化疾病发作的合适方法，以及确定压力时机与发作开始之间可被视为合理关联的时间点。虽然在理解对急性压力的生理反应方面已取得进展，但尚不清楚是急性、慢性还是反复性压力可能对慢性炎症性疾病影响最大。就IBD而言，疾病本身给患者带来压力，这进一步使问题变得模糊不清。
