Kats Lev M, Black Casilda G, Proellocks Nicholas I, Coppel Ross L
Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia.
Trends Parasitol. 2006 Jun;22(6):269-76. doi: 10.1016/j.pt.2006.04.001. Epub 2006 Apr 25.
Plasmodium parasites have three sets of specialised secretory organelles at the apical end of their invasive forms--rhoptries, micronemes and dense granules. The contents of these organelles are responsible for or contribute to host cell invasion and modification, and at least four apical proteins are leading vaccine candidates. Given the unusual nature of Plasmodium invasion, it is not surprising that unique proteins are involved in this process. Nowhere is this more evident than in rhoptries. We have collated data from several recent studies to compile a rhoptry proteome. Discussion is focussed here on rhoptry content and function.
疟原虫寄生虫在其侵袭性形态的顶端有三组专门的分泌细胞器——棒状体、微线体和致密颗粒。这些细胞器的内容物负责或有助于宿主细胞的侵袭和修饰，并且至少有四种顶端蛋白是主要的疫苗候选物。鉴于疟原虫侵袭的独特性质，参与这一过程的独特蛋白质并不奇怪。这在棒状体中最为明显。我们整理了最近几项研究的数据，汇编了一份棒状体蛋白质组。这里重点讨论棒状体的内容和功能。
