Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX, United States.
Front Immunol. 2020 Oct 29;11:594653. doi: 10.3389/fimmu.2020.594653. eCollection 2020.
Malaria remains a significant contributor to the global burden of disease, with around 40% of the world's population at risk of infections. The development of an effective vaccine against the malaria parasite would mark a breakthrough in the fight to eradicate the disease. Over time, natural infection elicits a robust immune response against the blood stage of the parasite, providing protection against malaria. In recent years, we have gained valuable insight into the mechanisms by which IgG acts to prevent pathology and inhibit parasite replication, as well as the potential role of immunoglobulin M (IgM) in these processes. Here, we discuss recent advances in our understanding of the mechanisms, acquisition, and maintenance of naturally acquired immunity, and the relevance of these discoveries for the development of a potential vaccine against the blood stage of .
疟疾仍然是全球疾病负担的一个重要因素，全球约有 40%的人口面临感染的风险。开发出一种针对疟原虫的有效疫苗将标志着消灭这种疾病的斗争取得突破。随着时间的推移，自然感染会引发针对寄生虫血阶段的强大免疫反应，从而提供对疟疾的保护。近年来，我们深入了解了 IgG 预防发病机制和抑制寄生虫复制的作用机制，以及 IgM 在这些过程中的潜在作用。在这里，我们讨论了对自然获得性免疫的机制、获得和维持的理解的最新进展，以及这些发现对开发针对疟原虫血阶段的潜在疫苗的相关性。
