Decker Carolyn J, Parker Roy
Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, University of Arizona, Tucson, 85721, USA.
J Cell Biol. 2006 Apr 24;173(2):159-63. doi: 10.1083/jcb.200601153.
The targeting of messenger RNAs (mRNAs) to specific subcellular sites for local translation plays an important role in diverse cellular and developmental processes in eukaryotes, including axis formation, cell fate determination, spindle pole regulation, cell motility, and neuronal synaptic plasticity. Recently, a new conserved class of Lsm proteins, the Scd6 family, has been implicated in controlling mRNA function. Depletion or mutation of members of the Scd6 family, Caenorhabditis elegans CAR-1 and Drosophila melanogaster trailer hitch, lead to a variety of developmental phenotypes, which in some cases can be linked to alterations in the endoplasmic reticulum (ER). Scd6/Lsm proteins are RNA binding proteins and are found in RNP complexes associated with translational control of mRNAs, and these complexes can colocalize with the ER. These findings raise the possibility that localization and translational regulation of mRNAs at the ER plays a role in controlling the organization of this organelle.
信使核糖核酸（mRNA）靶向特定亚细胞位点进行局部翻译，在真核生物的多种细胞和发育过程中发挥着重要作用，包括轴形成、细胞命运决定、纺锤极调节、细胞运动以及神经元突触可塑性。最近，一类新的保守Lsm蛋白家族——Scd6家族，被认为参与控制mRNA功能。秀丽隐杆线虫的CAR-1和黑腹果蝇的trailer hitch等Scd6家族成员的缺失或突变，会导致多种发育表型，在某些情况下这些表型可与内质网（ER）的改变相关联。Scd6/Lsm蛋白是RNA结合蛋白，存在于与mRNA翻译控制相关的核糖核蛋白复合物中，并且这些复合物可与内质网共定位。这些发现增加了内质网处mRNA的定位和翻译调控在控制该细胞器组织中起作用的可能性。
