Li Jia-Ling, Canham Russell M, Vongpatanasin Wanpen, Leonard David, Auchus Richard J, Victor Ronald G
Division of Hypertension, Department of Internal Medicine, Donald W. Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, USA.
Hypertension. 2006 Jun;47(6):1140-6. doi: 10.1161/01.HYP.0000217972.80731.ef. Epub 2006 Apr 24.
Sequence variations in the human alpha2 adrenergic receptor genes (ADRA2A and ADRA2C) have been implicated as a cause of hypertension in blacks. Although certain alleles are selectively enriched in blacks, their association with hypertension is based on small convenience samples and has not been evaluated in larger populations. From a stratified random population sample of 3398 individuals (52% blacks), we obtained DNA samples together with an in-home health interview, 10 in-home measurements of blood pressure, and cardiac MRI. We tested for associations among hypertension, untreated blood pressure, and parameters of hypertensive heart disease with 2 alleles, a DraI restriction fragment length polymorphism in the ADRA2A gene and a deletion of residues 322 to 325 in the ADRA2C gene. Although both alleles were selectively enriched in this black population, we found no association of either allele with hypertension, untreated blood pressure, or any of the cardiac function parameters. In a logistic model that controlled for age, body mass index, diabetes, and smoking, the adjusted odds ratio (OR) for hypertension was 1.0 (95% CI, 0.8 to 1.2), and 1.0 (95% CI, 0.9 to 1.2) for ADRA2A and ADRA2C variant alleles. In subjects not receiving prescription blood pressure medication, neither of these alleles, alone or in combination, was predictive of blood pressure, heart rate, left ventricular mass, cardiac output, systemic vascular resistance, or aortic compliance. Both the DraI restriction fragment length polymorphism in ADRA2A and the ADRA2C (Del 322 to 325) can be excluded as major candidate alleles for hypertension in blacks.
人类α2肾上腺素能受体基因（ADRA2A和ADRA2C）的序列变异被认为是黑人高血压的一个病因。尽管某些等位基因在黑人中选择性富集，但其与高血压的关联基于小样本的便利抽样，尚未在更大规模人群中进行评估。我们从一个包含3398名个体（52%为黑人）的分层随机人群样本中，获取了DNA样本，并进行了家庭健康访谈、10次家庭血压测量以及心脏磁共振成像检查。我们检测了高血压、未治疗的血压以及高血压性心脏病参数与两个等位基因之间的关联，这两个等位基因分别是ADRA2A基因中的Dral限制性片段长度多态性以及ADRA2C基因中322至325位残基的缺失。尽管这两个等位基因在该黑人人群中均有选择性富集，但我们发现它们与高血压、未治疗的血压或任何心脏功能参数均无关联。在一个控制了年龄、体重指数、糖尿病和吸烟因素的逻辑模型中，ADRA2A和ADRA2C变异等位基因导致高血压的调整优势比（OR）分别为1.0（95%可信区间，0.8至1.2）和1.0（95%可信区间，0.9至1.2）。在未服用处方降压药的受试者中，这两个等位基因单独或联合使用均不能预测血压、心率、左心室质量、心输出量、全身血管阻力或主动脉顺应性。ADRA2A中的Dral限制性片段长度多态性和ADRA2C（Del 322至325）均可被排除为黑人高血压的主要候选等位基因。
