非裔美国人和白人的教育、遗传血统与血压。
Education, genetic ancestry, and blood pressure in African Americans and Whites.
机构信息
Harvard Center for Population and Development Studies, Harvard University, Cambridge, MA 02138, USA.
出版信息
Am J Public Health. 2012 Aug;102(8):1559-65. doi: 10.2105/AJPH.2011.300448. Epub 2012 Jun 14.
OBJECTIVES
We assessed the relative roles of education and genetic ancestry in predicting blood pressure (BP) within African Americans and explored the association between education and BP across racial groups.
METHODS
We used t tests and linear regressions to examine the associations of genetic ancestry, estimated from a genomewide set of autosomal markers, and education with BP variation among African Americans in the Family Blood Pressure Program. We also performed linear regressions in self-identified African Americans and Whites to explore the association of education with BP across racial groups.
RESULTS
Education, but not genetic ancestry, significantly predicted BP variation in the African American subsample (b=-0.51 mm Hg per year additional education; P=.001). Although education was inversely associated with BP in the total population, within-group analyses showed that education remained a significant predictor of BP only among the African Americans. We found a significant interaction (b=3.20; P=.006) between education and self-identified race in predicting BP.
CONCLUSIONS
Racial disparities in BP may be better explained by differences in education than by genetic ancestry. Future studies of ancestry and disease should include measures of the social environment.
目的
我们评估了教育和遗传背景在预测非裔美国人血压（BP）方面的相对作用，并探讨了教育与不同种族群体之间 BP 之间的关系。
方法
我们使用 t 检验和线性回归来检查全基因组常染色体标记物估算的遗传背景和教育与家庭血压计划中非洲裔美国人的 BP 变化之间的关联。我们还在自我认同的非裔美国人和白人中进行线性回归，以探讨教育与不同种族群体之间 BP 的关系。
结果
教育而非遗传背景显著预测了非洲裔美国人亚组的 BP 变化（每增加一年教育，BP 下降 0.51 毫米汞柱；P=.001）。尽管教育与总体人群中的 BP 呈负相关，但组内分析表明，仅在非裔美国人中，教育仍然是 BP 的重要预测因素。我们发现，在预测 BP 方面，教育与自我认同种族之间存在显著的交互作用（b=3.20；P=.006）。
结论
BP 的种族差异可能更多地可以通过教育差异来解释，而不是遗传背景。未来对遗传背景和疾病的研究应包括社会环境的衡量标准。
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