Sutidze M, Sulakvelidze M, Kochiashvili D, Labadze D, Rukhadze I
Department of Hemodialysis and Detoxication, Tbilisis State Medical University Clinic, Georgia.
Georgian Med News. 2006 Mar(132):68-71.
We designed this study to compare serum markers of myocardial injury creatine kinase MB (CK-MB), as well, as serum contractile proteins, especially cardiac troponin T (cTnT) and cardiac troponin I (cTnI) in dialysis patients without acute ischemic heart disease. 24 patients on chronic hemodialysis were studied by history and physical examination, electrocardiography, and two-dimensional echocardiography. These patients had no evidence of ischemic heart disease. Biochemical markers were measured in serial predialysis blood samples with specific monoclonal antibody-based immunoassays. For several patients at least one sample measured above the upper reference limit: CK-MB, 7 of 24 (30%); ELISA cTnT, 17 of 24 (71%); Enzymun cTnT, 3 of 18 (17%); and cTnI, 1 of 24 (4%). Chronic dialysis patients without acute ischemic heart disease frequently had increased serum CK-MB and cTnT. Our finding are in agreement with the conclusions that cTnT and CK-MB detected in the serum of patients on chronic hemodialysis originates from the skeletal muscle and not from the heart.
我们开展这项研究，以比较无急性缺血性心脏病的透析患者的心肌损伤血清标志物肌酸激酶同工酶MB（CK-MB）以及血清收缩蛋白，尤其是心肌肌钙蛋白T（cTnT）和心肌肌钙蛋白I（cTnI）。通过病史及体格检查、心电图和二维超声心动图对24例慢性血液透析患者进行了研究。这些患者无缺血性心脏病证据。采用基于特异性单克隆抗体的免疫测定法，对透析前系列血样中的生化标志物进行检测。部分患者至少有一份样本的检测值高于参考上限：CK-MB，24例中有7例（30%）；酶联免疫吸附测定法检测cTnT，24例中有17例（71%）；酶免疫法检测cTnT，18例中有3例（17%）；cTnI，24例中有1例（4%）。无急性缺血性心脏病的慢性透析患者血清CK-MB和cTnT常常升高。我们的研究结果与以下结论一致，即慢性血液透析患者血清中检测到的cTnT和CK-MB源自骨骼肌而非心脏。
