Yamamoto Yukiko, Oue Eriko
Graduate School of Human Life Science, Osaka City University, Sumiyoshi-ku, Osaka, Japan.
Biosci Biotechnol Biochem. 2006 Apr;70(4):933-9. doi: 10.1271/bbb.70.933.
The effects of different levels of quercetin on the blood pressure were studied in 6-week-old male Sprague-Dawley rats. The rats were fed with a control diet or a high-fat high-sucrose (HFS) diet containing 0, 0.02, 0.07, 0.2, or 0.5% quercetin for 4 weeks. The systolic blood pressure and the lipid peroxides in the plasma were both higher in the rats fed with the HFS diet without quercetin than in the rats fed with the control diet. The nitric oxide synthase (NOS) activity in the vascular tissues and nitric oxide (NO) metabolites in the plasma and urine were both lower in these rats. A distinct depression of the increase in blood pressure was found in the rats fed with the HFS diets containing quercetin. Each level of quercetin examined was effective, the 0.5% level being much more effective than other levels. Dietary quercetin decreased lipid peroxidation in the plasma of the rats fed with the HFS diets. Quercetin also suppressed the decrease in NO metabolites in the plasma and urine, and the NOS activity in the vascular tissues of these rats. These results suggest that the increased NO availability caused by the elevated NOS activity, and the antioxidative activity in these rats fed with quercetin may be sources of the antihypertensive effect of quercetin.
在6周龄雄性斯普拉格-道利大鼠中研究了不同水平槲皮素对血压的影响。将大鼠分为两组，分别喂食对照饮食或含0%、0.02%、0.07%、0.2%或0.5%槲皮素的高脂高糖（HFS）饮食，持续4周。与喂食对照饮食的大鼠相比，喂食不含槲皮素的HFS饮食的大鼠收缩压和血浆中的脂质过氧化物均更高。这些大鼠血管组织中的一氧化氮合酶（NOS）活性以及血浆和尿液中的一氧化氮（NO）代谢产物均较低。在喂食含槲皮素的HFS饮食的大鼠中发现血压升高明显受到抑制。所检测的每个槲皮素水平均有效，其中0.5%水平比其他水平更有效。饮食中的槲皮素降低了喂食HFS饮食的大鼠血浆中的脂质过氧化。槲皮素还抑制了这些大鼠血浆和尿液中NO代谢产物的减少以及血管组织中的NOS活性。这些结果表明，在喂食槲皮素的大鼠中，NOS活性升高导致的NO可用性增加以及抗氧化活性可能是槲皮素降压作用的来源。
