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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Lavagno C, Giulivi C, Boveris A

Department of Physical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina.

Xenobiotica. 1991 Aug;21(8):1003-11. doi: 10.3109/00498259109039540.

Betamethasone (1 mg/ml) was administered i.v. to adult Wistar rats 3 h before paraquat injection (30 mg/ml) and various parameters of lung function were studied to determine the effect of an anti-inflammatory drug in paraquat lung toxicity. 2. Rats treated with both drugs showed not only increases in spontaneous lung chemiluminescence (90%), malondialdehyde formation (40%), migration of PMN cells to the lungs (450%) and lung wet wt (20%), but also the survival times were decreased to 25% at day 7. 3. The data indicate that betamethasone exacerbates the toxic effects of paraquat. The mechanism can be explained in terms of inhibition of phospholipase A2 activity, which may increase the accumulation of hydroperoxide, produced by paraquat redox cycling upon lipid membranes.

在给成年Wistar大鼠注射百草枯（30毫克/毫升）前3小时，静脉注射倍他米松（1毫克/毫升），并研究肺功能的各项参数，以确定一种抗炎药物对百草枯肺毒性的影响。2. 同时接受两种药物治疗的大鼠不仅自发性肺化学发光增加（90%）、丙二醛形成增加（40%）、PMN细胞向肺的迁移增加（450%）以及肺湿重增加（20%），而且在第7天时存活时间缩短至25%。3. 数据表明倍他米松会加剧百草枯的毒性作用。其机制可以用磷脂酶A2活性的抑制来解释，这可能会增加脂质膜上百草枯氧化还原循环产生的氢过氧化物的积累。

Lavagno C, Giulivi C, Boveris A

Department of Physical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina.

Xenobiotica. 1991 Aug;21(8):1003-11. doi: 10.3109/00498259109039540.

Betamethasone (1 mg/ml) was administered i.v. to adult Wistar rats 3 h before paraquat injection (30 mg/ml) and various parameters of lung function were studied to determine the effect of an anti-inflammatory drug in paraquat lung toxicity. 2. Rats treated with both drugs showed not only increases in spontaneous lung chemiluminescence (90%), malondialdehyde formation (40%), migration of PMN cells to the lungs (450%) and lung wet wt (20%), but also the survival times were decreased to 25% at day 7. 3. The data indicate that betamethasone exacerbates the toxic effects of paraquat. The mechanism can be explained in terms of inhibition of phospholipase A2 activity, which may increase the accumulation of hydroperoxide, produced by paraquat redox cycling upon lipid membranes.

在给成年Wistar大鼠注射百草枯（30毫克/毫升）前3小时，静脉注射倍他米松（1毫克/毫升），并研究肺功能的各项参数，以确定一种抗炎药物对百草枯肺毒性的影响。2. 同时接受两种药物治疗的大鼠不仅自发性肺化学发光增加（90%）、丙二醛形成增加（40%）、PMN细胞向肺的迁移增加（450%）以及肺湿重增加（20%），而且在第7天时存活时间缩短至25%。3. 数据表明倍他米松会加剧百草枯的毒性作用。其机制可以用磷脂酶A2活性的抑制来解释，这可能会增加脂质膜上百草枯氧化还原循环产生的氢过氧化物的积累。