Olivares Mónica, Díaz-Ropero M Paz, Gómez Nuria, Lara-Villoslada Federico, Sierra Saleta, Maldonado Juan A, Martín Rocío, Rodríguez Juan M, Xaus Jordi
Immunology and Animal Science Department, Puleva Biotech SA, Granada, Spain.
Int Microbiol. 2006 Mar;9(1):47-52.
Orally ingested probiotic bacteria are able to modulate the immune system. However, differences exist in the immunomodulatory effects of different probiotic strains. Moreover, different regulatory effects, which depend on the health status of the consumer, have been identified. This work describes a randomized, double-blind, placebo-controlled human clinical trial to investigate the immune effects on healthy people of a fermented product containing two new probiotic strains, Lactobacillus gasseri CECT 5714 and Lactobacillus coryniformis CECT 5711, which was compared with another fermented product, a standard yogurt. Consumption of either the new product or yogurt increased the proportion of phagocytic cells, including monocytes and neutrophils, as well as their phagocytic activity. However, combination of the product containing the strains L. gasseri CECT 5714 and L. coryniformis CECT 5711 also induced an increase in the proportion of natural killer (NK) cells and in IgA concentrations. The effects were higher after two weeks of treatment than after 4 weeks, which suggests regulation of the immune system. In addition, the new product enhanced immunity in the participants to a greater extent than did the control standard yogurt.
口服益生菌能够调节免疫系统。然而，不同益生菌菌株的免疫调节作用存在差异。此外，还发现了取决于消费者健康状况的不同调节作用。这项工作描述了一项随机、双盲、安慰剂对照的人体临床试验，以研究一种含有两种新益生菌菌株——加氏乳杆菌CECT 5714和棒状乳杆菌CECT 5711的发酵产品对健康人的免疫作用，并将其与另一种发酵产品——标准酸奶进行比较。食用新产品或酸奶均增加了吞噬细胞（包括单核细胞和中性粒细胞）的比例及其吞噬活性。然而，含有加氏乳杆菌CECT 5714和棒状乳杆菌CECT 5711菌株的产品组合还诱导了自然杀伤（NK）细胞比例和IgA浓度的增加。治疗两周后的效果比4周后更高，这表明免疫系统受到了调节。此外，新产品比对照标准酸奶在更大程度上增强了参与者的免疫力。
