Uchikova E, Batashki I, Milchev N, Mateva N, Markova D, Gŭrova A
Akush Ginekol (Sofiia). 2006;45(2):39-43.
We present the influence of monophasic combined oral contraceptive with 20 mmicrog ethinylestradiol /150 microg desogestrel upon some acute phase proteins: C- reactive protein, fibrinogen, haptoglobin and the connection between the proinflammatory effect of oestrogens
Forty clinically healthy young women between 18 and 35 years, using oral contraceptives in the duration of 12 months, are included in this study.
We don't find statistically significant differences in the plasma concentrations of C--reactive protein, fibrinogen, haptoglobin on the 12th month of the using of the oral contraceptives in comparision with the initial levels of the variables, before starting the study.
The reduction of the dose of ethinylestradiol, definitely reduces the effects of oral contraceptives upon acute phase proteins and eventually the increased risk of cardiovascular disease.
我们阐述了含20微克炔雌醇/150微克去氧孕烯的单相复方口服避孕药对一些急性期蛋白的影响：C反应蛋白、纤维蛋白原、触珠蛋白以及雌激素的促炎作用之间的联系。
本研究纳入了40名年龄在18至35岁之间、服用口服避孕药12个月的临床健康年轻女性。
与研究开始前变量的初始水平相比，在服用口服避孕药第12个月时，我们未发现血浆中C反应蛋白、纤维蛋白原、触珠蛋白的浓度有统计学显著差异。
炔雌醇剂量的降低肯定会减少口服避孕药对急性期蛋白的影响，并最终降低心血管疾病风险的增加。
