Shishkina L N, Khrustova N V
Biofizika. 2006 Mar-Apr;51(2):340-6.
The results of long-time research of antioxidative activity (AOA) of lipids from tissues of different species and lines of laboratory rodents are generalized. The classification of lipids according to their ability to inhibit the thermal autooxidation of methyl oleate is proposed. The participation of lipids in low-temperature autooxidation reactions at the initiation and chain propagation stages was proved by means of the model proposed. In addition to the lipid antioxidative activity, the initial quantity of peroxides in lipids due to the extent of their unsaturation and lipid antiperoxide activity are proposed for the estimation of the kinetic characteristics of lipids. The dependence of effects on the rate of radical initiation in the system is shown to be caused by the influence of physicochemical properties of lipids on the interrelation coordination and balance of biochemical functions in biological objects differing in the intensity of oxidation processes.
概括了对不同种类和品系实验啮齿动物组织中脂质抗氧化活性(AOA)的长期研究结果。提出了根据脂质抑制油酸甲酯热自动氧化能力的脂质分类方法。通过所提出的模型证明了脂质在低温自动氧化反应的引发和链传播阶段的参与。除了脂质抗氧化活性外,还提出根据脂质中过氧化物的初始量、不饱和度以及脂质抗过氧化物活性来评估脂质的动力学特征。结果表明,效应与体系中自由基引发速率的依赖关系是由脂质的物理化学性质对氧化过程强度不同的生物对象中生化功能的相互关系协调和平衡的影响所导致的。