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[不同年龄大鼠组织和脂质的抗氧化活性]

[The antioxidative activity of the tissues and lipids in rats of different ages].

作者信息

Paranich A V, Kopylov A V, Diarra A, Nikipela O H

出版信息

Fiziol Zh (1994). 1995 Jan-Apr;41(1-2):29-36.

PMID:8846324
Abstract

The experiment on white Wistar rats 3-, 12- and 24 months old was carried out to study antioxidative activity in homogenates of the pancreas, adrenal glands, testes, muscles, heart and in lipids isolated from these tissues. The data were obtained in the model of thermal autooxidation of homogenates and lipids as well as during autooxidation of linethol in the presence of the samples studied. kinetics of peroxidation of tissue lipids, their effect on linethol oxidation rate and content of total lipids in the tissues were estimated. Contribution of the lipids to the total antioxidative activity of the tissue varies with age. Tissue properties of the parameters in question are observed as well as active participation of all the tissues studied in the support of the antioxidative homeostasis in the organism. Intensity of the participation depended on the age of animals.

摘要

对3个月、12个月和24个月大的白色Wistar大鼠进行了实验,以研究胰腺、肾上腺、睾丸、肌肉、心脏匀浆以及从这些组织中分离出的脂质中的抗氧化活性。数据是在匀浆和脂质的热自动氧化模型中以及在所研究样品存在下亚麻醇自动氧化过程中获得的。评估了组织脂质过氧化的动力学、它们对亚麻醇氧化速率的影响以及组织中总脂质的含量。脂质对组织总抗氧化活性的贡献随年龄而变化。观察到了所讨论参数的组织特性以及所有研究组织在维持机体抗氧化稳态中的积极参与。参与强度取决于动物的年龄。

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