Folmer-Andersen J Frantz, Kitamura Masanori, Anslyn Eric V
Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA.
J Am Chem Soc. 2006 May 3;128(17):5652-3. doi: 10.1021/ja061313i.
This manuscript describes an optical enantioselective pattern-based sensing array. A differential array of enantioselective indicator displacement assays was constructed and used to demonstrate simultaneous discrimination of enantiomeric and structurally similar alpha-amino acids. Interpretation of the output patterns by principle component analysis leads to the separation of enantio- and chemoselective information along orthogonal variance axes when chiral receptors of opposite enantiomeric preference are included. A general principle is delineated that correlates array design with the achievement of enantiomeric discrimination analogous to the mammalian gustation response to the amino acids.
本手稿描述了一种基于光学对映选择性模式的传感阵列。构建了对映选择性指示剂置换测定的差分阵列，并用于证明对映体和结构相似的α-氨基酸的同时鉴别。当包含对映体偏好相反的手性受体时，通过主成分分析对输出模式进行解释，可导致对映选择性和化学选择性信息沿着正交方差轴分离。阐述了一个一般原则，该原则将阵列设计与对映体鉴别成果相关联，类似于哺乳动物对氨基酸的味觉反应。
