使用纳米颗粒的基于阵列的传感：癌症诊断的替代方法。
Array-based sensing using nanoparticles: an alternative approach for cancer diagnostics.
作者信息
Le Ngoc D B, Yazdani Mahdieh, Rotello Vincent M
机构信息
Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA.
出版信息
Nanomedicine (Lond). 2014 Jul;9(10):1487-98. doi: 10.2217/nnm.14.65.
Array-based sensing using nanoparticles (NPs) provides an attractive alternative to specific biomarker-focused strategies for cancer diagnosis. The physical and chemical properties of NPs provide both the recognition and transduction capabilities required for biosensing. Array-based sensors utilize a combined response from the interactions between sensors and analytes to generate a distinct pattern (fingerprint) for each analyte. These interactions can be the result of either the combination of multiple specific biomarker recognition (specific binding) or multiple selective binding responses, known as chemical nose sensing. The versatility of the latter array-based sensing using NPs can facilitate the development of new personalized diagnostic methodologies in cancer diagnostics, a necessary evolution in the current healthcare system to better provide personalized treatments. This review will describe the basic principle of array-based sensors, along with providing examples of both invasive and noninvasive samples used in cancer diagnosis.
使用纳米颗粒（NPs）的基于阵列的传感为癌症诊断中以特定生物标志物为重点的策略提供了一种有吸引力的替代方案。纳米颗粒的物理和化学性质提供了生物传感所需的识别和转导能力。基于阵列的传感器利用传感器与分析物之间相互作用的组合响应，为每种分析物生成独特的模式（指纹）。这些相互作用可以是多种特定生物标志物识别（特异性结合）或多种选择性结合响应（称为化学鼻传感）组合的结果。后者使用纳米颗粒的基于阵列的传感的多功能性可以促进癌症诊断中新的个性化诊断方法的开发，这是当前医疗保健系统中更好地提供个性化治疗的必要发展。本综述将描述基于阵列的传感器的基本原理，并提供癌症诊断中使用的侵入性和非侵入性样本的示例。
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