Vun Yin, De'Ambrosis Brian, Spelman Lynda, Muir James B, Yong-Gee Simon, Wagner Godfrey, Lun Karyn
South East Dermatology, Carina Heights, Queensland, Australia.
Australas J Dermatol. 2006 May;47(2):106-8. doi: 10.1111/j.1440-0960.2006.00242.x.
A retrospective study of 813 histological specimens reported as seborrhoeic keratoses included 43 (5.3%) associated with non-melanoma skin cancer. Intraepidermal carcinoma (squamous cell carcinoma in situ) was the most common of these (36). There were five basal cell carcinomas (one with intraepidermal carcinoma also) and two invasive squamous cell carcinomas. No melanomas were reported. Twenty-seven of the intraepidermal carcinomas appeared to arise within the seborrhoeic keratosis as did one of the invasive squamous cell carcinomas. Of these 28 lesions, the head was the most common site. Fourteen were clinically diagnosed as a non-melanoma skin cancer with only nine clinically felt to be a seborrhoeic keratosis. These lesions may represent malignant transformation within the seborrhoeic keratosis. Twelve specimens reported adjacent dual pathologies, with the trunk and limbs the most common sites. Seven were diagnosed clinically as a skin malignancy, whereas three were thought to be solar keratoses. Clinically, the remaining two were seborrhoeic keratoses. The origin of the malignancy in these cases is less obvious and may represent collision tumours. Three curette specimens could not be assessed for architecture.
一项对813份报告为脂溢性角化病的组织学标本的回顾性研究发现，其中43份（5.3%）与非黑色素瘤皮肤癌相关。表皮内癌（原位鳞状细胞癌）是其中最常见的类型（36例）。有5例基底细胞癌（其中1例也伴有表皮内癌）和2例浸润性鳞状细胞癌。未报告有黑色素瘤。27例表皮内癌似乎起源于脂溢性角化病内部，1例浸润性鳞状细胞癌也是如此。在这28个病变中，头部是最常见的部位。14例临床诊断为非黑色素瘤皮肤癌，只有9例临床认为是脂溢性角化病。这些病变可能代表脂溢性角化病内的恶性转化。12份标本报告有相邻的双重病变，躯干和四肢是最常见的部位。7例临床诊断为皮肤恶性肿瘤，而3例被认为是日光性角化病。临床上，其余2例为脂溢性角化病。这些病例中恶性肿瘤的起源不太明显，可能代表碰撞瘤。3份刮除术标本无法评估其结构。
