Halfon P, Bourlière M, Pol S, Benhamou Y, Ouzan D, Rotily M, Khiri H, Renou C, Pénaranda G, Saadoun D, Thibault V, Serpaggi J, Varastet M, Tainturier M-H, Poynard T, Cacoub P
Alphabio Laboratory, Marseille, France.
J Viral Hepat. 2006 May;13(5):329-35. doi: 10.1111/j.1365-2893.2005.00692.x.
The clinical significance of hepatitis B virus (HBV) genotypes is still under debate. The aims of this study were to assess the distribution of HBV genotypes in France and to identify the associations between HBV genotypes and patient demographics, severity of liver disease and HBeAg status in patients referred to tertiary care centres. This was a French, multicentre, retrospective study on 262 patients with chronic HBV infection. HBV genotypes were determined using INNO-LiPA. Liver fibrosis damage was evaluated by histological analysis of biopsy samples. Patients were mainly male (74%), of Caucasian (65%), Asian (17%) or African (18%) ethnicity and 36% were HBeAg positive. All A-G genotypes were found, the most frequent being genotypes D (27%) and A (24%), followed by E (13%) and C (12%), and B (7%). Mixed genotypes were detected in 16% of the cases. Genotype A was associated with sexual contact (P < 0.001) and genotype D with transfusion (P < 0.001) and HBe antibody positivity (P = 0.03).The distribution of HBV genotypes differed with regard to the ethnicity, and may reflect migration patterns. Genotypes A and D were the most frequent in France. Genotype A was associated with HBeAg positivity and genotype D with HBe antibody positivity. In our European patients, we find no clear association between a given HBV genotype and liver disease severity.
乙型肝炎病毒（HBV）基因型的临床意义仍存在争议。本研究的目的是评估法国HBV基因型的分布情况，并确定在三级医疗中心就诊的患者中HBV基因型与患者人口统计学特征、肝病严重程度以及HBeAg状态之间的关联。这是一项针对262例慢性HBV感染患者的法国多中心回顾性研究。使用INNO-LiPA法确定HBV基因型。通过对活检样本进行组织学分析来评估肝纤维化损伤情况。患者主要为男性（74%），种族为白种人（65%）、亚洲人（17%）或非洲人（18%），36%的患者HBeAg呈阳性。所有A - G基因型均被发现，最常见的是D基因型（27%）和A基因型（24%），其次是E基因型（13%）和C基因型（12%），以及B基因型（7%）。16%的病例检测到混合基因型。A基因型与性接触相关（P < 0.001），D基因型与输血相关（P < 0.001）以及与HBe抗体阳性相关（P = 0.03）。HBV基因型的分布在种族方面存在差异，可能反映了移民模式。A和D基因型在法国最为常见。A基因型与HBeAg阳性相关，D基因型与HBe抗体阳性相关。在我们的欧洲患者中，未发现特定HBV基因型与肝病严重程度之间存在明确关联。
