Msuya C A, Hartveit F
Department of Pathology, Gade Institute, University of Bergen, Norway.
Breast Cancer Res Treat. 1991 Nov;19(3):277-81. doi: 10.1007/BF01961164.
The term 'skip lesion', referring to a tumour-bearing node in the axilla in breast cancer, presupposes that nodal colonization usually occurs in sequence with the path of the lymph flow. Skip lesions are thus out of step with the system. The present study of axillary nodes from 73 node-positive patients demonstrates that skip lesions have much in common with lone micrometastases found at any level, and are thus but a variant of the pattern found in early colonization of the axilla. This in turn indicates that in contrast to a progressive build up of tumour growth first at the lower and later at the middle level, early colonization may be a random process. This again stresses the importance of nodal dissection versus biopsy in the management of breast cancer, particularly in view of recent reports on the prognostic significance of micrometastases.
“跳跃性病变”一词指乳腺癌腋窝处有肿瘤的淋巴结，其前提是淋巴结转移通常按照淋巴液流动路径依次发生。因此，跳跃性病变与该系统不一致。本研究对73例淋巴结阳性患者的腋窝淋巴结进行了分析，结果表明，跳跃性病变与在任何水平发现的孤立微转移有许多共同之处，因此只是腋窝早期转移模式的一种变体。这反过来表明，与肿瘤生长首先在较低水平然后在中间水平逐渐累积不同，早期转移可能是一个随机过程。这再次强调了在乳腺癌治疗中淋巴结清扫与活检相比的重要性，特别是考虑到最近关于微转移预后意义的报道。
