Olsen K A, Rosenbaum B
Centre of Psychiatry, Glostrup Copenhagen County University Hospital, Ndr. Ringvej, DK-2600 Glostrup, Denmark.
Acta Psychiatr Scand. 2006 Apr;113(4):247-72. doi: 10.1111/j.1600-0447.2005.00697.x.
The paper presents a comprehensive overview of prospective studies monitoring or intervening in the pre-onset phase of first episode psychosis.
A systematic literature search was conducted and supplemented by a manual search. All relevant studies were ordered and intensively reviewed according to specified criteria. Methodological and conceptual issues are discussed.
Reports of 23 prospective studies were found, some describing subsamples of larger samples. Major methodological and conceptual divergences exist.
Applied criteria detect individuals with a significantly increased risk of psychosis within the schizophrenia spectrum, but these criteria are only validated on clinical populations. The significance of differences in sample-characteristics is unclear. Most study samples are small. Results are preliminary and in need of further research before they constitute a realistic knowledge base. Methodological and conceptual issues should not be underestimated.
本文全面概述了监测或干预首发精神病发病前期的前瞻性研究。
进行了系统的文献检索，并辅以人工检索。所有相关研究均按照特定标准进行整理和深入审查。讨论了方法学和概念性问题。
共找到23项前瞻性研究报告，其中一些描述了较大样本中的子样本。存在主要的方法学和概念性差异。
应用的标准可检测出精神分裂症谱系内精神病风险显著增加的个体，但这些标准仅在临床人群中得到验证。样本特征差异的意义尚不清楚。大多数研究样本较小。结果是初步的，在构成现实的知识库之前需要进一步研究。方法学和概念性问题不应被低估。
