Lin Ho-Hsiung, Wu Wen-Yih, Kao Jia-Horng, Chen Ding-Shin
Department of Obstetrics and Gynecology, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan.
J Gastroenterol Hepatol. 2006 Mar;21(3):605-9. doi: 10.1111/j.1440-1746.2006.04198.x.
The purpose of the present paper was to correlate hepatitis B virus (HBV) genotype, e antigen titer, HBV-DNA level and precore/basal core promoter mutations with post-partum e antigen clearance in hepatitis B e antigen (HBeAg)-positive carrier mothers.
A total of 40 consecutive HBeAg-positive carrier mothers were studied from January 2002 to January 2003. The blood samples were taken at delivery, 3-4 months and at 1 year after delivery, and the follow-up period was until 1 year after delivery. All sera were assayed for HBeAg, HBV-DNA level, HBV genotype and precore/basal core promoter mutations. The correlation between HBV characteristics and post-partum e antigen clearance was analyzed by Mann-Whitney, Pearson chi2 and multiple logistic regression tests.
The mean age of the 40 HBeAg-positive carrier mothers was 29.9 +/- 5.3 years with a mean parity of 1.4 +/- 0.7. Five of them (group I) had post-partum e antigen clearance, which persisted thereafter, whereas the remaining 35 carrier mothers (group II) had persistent positivity of HBeAg during the follow-up period. The prepartum comparisons of HBV characteristics between groups I and II were comparable in terms of demographics and distributions of HBV genotype and precore/basal core promoter mutations. In contrast, group I carrier mothers had lower HBeAg titer and HBV-DNA level than group II carrier mothers (1:80 vs 1:4000, P = 0.02, and 3.75 x 10(5) vs 3 x 10(8) copies/mL, P = 0.028, respectively).
Post-partum e antigen clearance in HBeAg-positive carrier mothers is closely associated with prepartum low HBeAg titer or HBV-DNA level.
本文旨在探讨乙肝病毒（HBV）基因型、e抗原滴度、HBV-DNA水平以及前核心/基础核心启动子突变与乙肝e抗原（HBeAg）阳性携带者母亲产后e抗原清除之间的相关性。
2002年1月至2003年1月，对40例连续的HBeAg阳性携带者母亲进行了研究。在分娩时、分娩后3 - 4个月及1年采集血样，随访期至分娩后1年。对所有血清进行HBeAg、HBV-DNA水平、HBV基因型及前核心/基础核心启动子突变检测。采用Mann-Whitney检验、Pearson卡方检验及多元逻辑回归分析HBV特征与产后e抗原清除之间的相关性。
40例HBeAg阳性携带者母亲的平均年龄为29.9±5.3岁，平均产次为1.4±0.7。其中5例（第一组）产后e抗原清除且持续保持，而其余35例携带者母亲（第二组）在随访期间HBeAg持续阳性。第一组和第二组母亲在人口统计学特征、HBV基因型及前核心/基础核心启动子突变分布方面的HBV特征产前比较无差异。相比之下，第一组携带者母亲的HBeAg滴度和HBV-DNA水平低于第二组携带者母亲（分别为1:80 vs 1:4000，P = 0.02；3.75×10⁵ vs 3×10⁸拷贝/mL，P = 0.028）。
HBeAg阳性携带者母亲产后e抗原清除与产前低HBeAg滴度或低HBV-DNA水平密切相关。
