Lin H H, Chen P J, Chen D S, Sung J L, Yang K H, Young Y C, Liou Y S, Chen Y P, Lee T Y
Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Republic of China.
J Med Virol. 1989 Sep;29(1):1-6. doi: 10.1002/jmv.1890290102.
To elucidate the effects of pregnancy and delivery on hepatitis B e antigen (HBeAg)-positive carrier mothers, 31 HBeAg-positive carrier mothers were followed-up postpartum 1 year, with 30 HBeAg-positive nonpregnant female carriers as controls. Serum hepatitis B surface antigen (HBsAg), HBeAg titer, and hepatitis B virus (HBV)-DNA concentration were studied at defined intervals. The results revealed that in the control group HBeAg titers and HBV-DNA concentrations fluctuated, whereas the HBsAg titers showed little change, but HBeAg clearance or seroconversion to anti-HBe were not noted on follow-up. In contrast, one carrier mother seroconverted to anti-HBe during pregnancy and the antibody persisted thereafter. Five of the remaining 30 carrier mothers cleared HBeAg postpartum, and among these five cases, one also seroconverted to anti-HBe. In addition, in another five of the 30 cases, the HBV-DNA fell to undetectable level (less than 0.04 ng/ml). All these ten cases had a common tendency of showing a decrease in HBeAg titers and/or HBV-DNA concentrations 1-2 months after delivery. The HBeAg titers and HBV-DNA concentrations in the other 11 cases remained unchanged, whereas the remaining nine cases had increased levels. It is concluded that subsidence of HBV replication is precipitated by delivery in one-third of HBeAg-positive carrier mothers in Taiwan, and this occurs most frequently 1-2 months postpartum.
为阐明妊娠和分娩对乙肝e抗原（HBeAg）阳性携带者母亲的影响，对31例HBeAg阳性携带者母亲产后进行了1年的随访，并以30例HBeAg阳性未孕女性携带者作为对照。在规定的时间间隔内研究血清乙肝表面抗原（HBsAg）、HBeAg滴度和乙肝病毒（HBV）-DNA浓度。结果显示，对照组中HBeAg滴度和HBV-DNA浓度有波动，而HBsAg滴度变化不大，但随访中未发现HBeAg清除或血清转换为抗-HBe。相比之下，1例携带者母亲在孕期血清转换为抗-HBe，且此后抗体持续存在。其余30例携带者母亲中有5例产后清除了HBeAg，其中1例也血清转换为抗-HBe。此外，在30例中的另外5例中，HBV-DNA降至检测不到的水平（低于0.04 ng/ml）。所有这10例都有一个共同趋势，即在分娩后1-2个月HBeAg滴度和/或HBV-DNA浓度下降。其他11例的HBeAg滴度和HBV-DNA浓度保持不变，而其余9例则升高。结论是，在台湾，三分之一的HBeAg阳性携带者母亲在分娩后乙肝病毒复制下降，这种情况最常发生在产后1-2个月。
