临床抑郁症患者抑郁症状、健康状况和生活质量变化的同步性。
Synchrony of change in depressive symptoms, health status, and quality of life in persons with clinical depression.
作者信息
Diehr Paula H, Derleth Ann M, McKenna Stephen P, Martin Mona L, Bushnell Donald M, Simon Gregory, Patrick Donald L
机构信息
Department of Biostatistics F-670 HSB, Box 357232, University of Washington, Seattle, WA 98195-7232, USA.
出版信息
Health Qual Life Outcomes. 2006 Apr 25;4:27. doi: 10.1186/1477-7525-4-27.
BACKGROUND
Little is known about longitudinal associations among measures of depression, mental and physical health, and quality of life (QOL). We followed 982 clinically depressed persons to determine which measures changed and whether the change was synchronous with change in depressive symptoms.
METHODS
Data were from the Longitudinal Investigation of Depression Outcomes (LIDO). Depressive symptoms, physical and mental health, and quality of life were measured at baseline, 6 weeks, 3 months, and 9 months. Change in the measures was examined over time and for persons with different levels of change in depressive symptoms.
RESULTS
On average, all of the measures improved significantly over time, and most were synchronous with change in depressive symptoms. Measures of mental health changed the most, and physical health the least. The measures of change in QOL were intermediate. The 6-week change in QOL could be explained completely by change in depressive symptoms. The instruments varied in sensitivity to changes in depressive symptoms.
CONCLUSION
In clinically depressed persons, measures of physical health, mental health, and quality of life showed consistent longitudinal associations with measures of depressive symptoms.
背景
关于抑郁、心理健康和身体健康以及生活质量（QOL）测量指标之间的纵向关联，人们所知甚少。我们对982名临床抑郁症患者进行了跟踪，以确定哪些测量指标发生了变化，以及这种变化是否与抑郁症状的变化同步。
方法
数据来自抑郁症结局纵向调查（LIDO）。在基线、6周、3个月和9个月时测量抑郁症状、身心健康和生活质量。随着时间推移，并针对抑郁症状变化程度不同的人群，对这些测量指标的变化进行了研究。
结果
平均而言，所有测量指标均随时间显著改善，且大多数与抑郁症状的变化同步。心理健康测量指标变化最大，身体健康测量指标变化最小。生活质量变化测量指标处于中间水平。生活质量6周时的变化可以完全由抑郁症状的变化来解释。这些工具对抑郁症状变化的敏感度各不相同。
结论
在临床抑郁症患者中，身体健康、心理健康和生活质量测量指标与抑郁症状测量指标之间呈现出一致的纵向关联。
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