Cilla G, Sarasua A, Montes M, Arostegui N, Vicente D, Pérez-Yarza E, Pérez-Trallero E
Servicio de Microbiología, Hospital Donostia, and Deparamento de Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad del País Vasco, San Sebastián, Spain.
Epidemiol Infect. 2006 Jun;134(3):506-13. doi: 10.1017/S0950268805005571.
This study analysed the role of several risk factors for hospitalization due to community-acquired, respiratory syncytial virus (RSV) infection. The risk factors detected in infants hospitalized for RSV infection in the first 24 months of life were compared with those in the general infant population in our region. There were 361 episodes of hospitalization in 357 infants. Eighty per cent of the infants did not present underlying conditions for severe RSV infection and only 10 (3%) were candidates for palivizumab prophylaxis. In multivariate analysis, birthweight of <2500 g was independently associated with hospitalization for RSV infection and was the most commonly detected medical risk factor. Other risk factors were maternal age at delivery <25 years, birth in the second half of the year, prematurity, suburban residence and congenital heart disease. In conclusion, together with well-known risk factors, we found that low birthweight was an independent factor for severe RSV infection.
本研究分析了几种社区获得性呼吸道合胞病毒（RSV）感染所致住院风险因素的作用。将24个月内因RSV感染住院的婴儿中检测到的风险因素与本地区普通婴儿群体中的风险因素进行比较。357名婴儿中有361次住院发作。80%的婴儿不存在严重RSV感染的基础疾病，仅有10名（3%）符合帕利珠单抗预防用药条件。多因素分析显示，出生体重<2500 g与RSV感染住院独立相关，是最常检测到的医学风险因素。其他风险因素包括分娩时母亲年龄<25岁、下半年出生、早产、居住在郊区以及先天性心脏病。总之，除了众所周知的风险因素外，我们发现低出生体重是严重RSV感染的独立因素。
