Gong Hui, Zhang Yi-Cheng, Liu Wen-Li
Department of Hematology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006 Apr;14(2):413-5.
Self-renewal of hematopoietic stem cells is vital for the sustained daily production of blood cells. The Bmi-1 gene is a putative oncogene belonging to the Polycomb group family. Recent studies have shown that the Polycomb-group gene Bmi-1 is indispensable for regulation of self-renewal of normal and leukemic stem cells. The research progress on structure and function of Bmi-1 gene, and its role in self-renewal of hematopoietic stem cells was reviewed.
造血干细胞的自我更新对于血细胞的持续日常生成至关重要。Bmi-1基因是一种推定的癌基因，属于多梳蛋白家族。最近的研究表明，多梳蛋白家族基因Bmi-1对于正常和白血病干细胞自我更新的调节不可或缺。本文综述了Bmi-1基因的结构和功能及其在造血干细胞自我更新中的作用的研究进展。
