Zhou Chao, Fang Ping, Liu You-ning, Hu Bin, Ding Hong-mei, Xu Xiao-ling, Wu Hao, Wang Jin, Lin Lin, Pan Hua, Wu Tong-sheng, Song You-liang
Department of Respiratory Medicine, the People's Hospital of Tongling, Anhui 244000, China.
Zhonghua Jie He He Hu Xi Za Zhi. 2006 Jan;29(1):9-13.
To describe the clinical features of the infection caused by the highly pathogenic avian influenza A (H(5)N(1)).
A previously healthy 24 year old woman presented to our hospital on November 7, 2005. She was confirmed to be an H(5)N(1) infected case after death. The clinical, radiological and epidemiological data were analyzed.
The patient had a history of direct contact with diseased and dead poultry (chicken and duck). The disease course was 10 days from onset of illness to death, and fever preceded dyspnea by 5 days. On admission, the striking characteristics were acute community-acquired pneumonia (CAP) and acute respiratory distress syndrome (ARDS), and the major radiographic abnormalities included extensive infiltration bilaterally, focal consolidation and air bronchograms. The radiographic and clinical deterioration was rapid, and the patient died in less than 3 days after hospitalization. The diagnosis of influenza A (H(5)N(1)) was confirmed by means of reverse transcriptase-polymerase chain reaction (RT-PCR) and real-time PCR on specimens of the lower respiratory tract, performed by Chinese Center for Disease Control. The postmortem examination showed bronchial hyperemia, extensive consolidation, serous cavity effusions, disseminated intravascular coagulation (DIC) and multiple organ failure (MOF).
Human infection by the highly pathogenic avian influenza A (H(5)N(1)) is a fatal communicable disease. Information of avian influenza A (H(5)N(1)) virus, more attention to the epidemiologic data, and early intervention are critical in reducing the mortality.
描述高致病性甲型禽流感（H(5)N(1)）感染的临床特征。
一名既往健康的24岁女性于2005年11月7日就诊于我院。死后被确诊为H(5)N(1)感染病例。对其临床、影像学和流行病学资料进行分析。
患者有直接接触病死家禽（鸡和鸭）的病史。病程从发病到死亡为10天，发热比呼吸困难早5天。入院时，显著特征为急性社区获得性肺炎（CAP）和急性呼吸窘迫综合征（ARDS），主要影像学异常包括双侧广泛浸润、局灶性实变和空气支气管征。影像学和临床病情迅速恶化，患者住院不到3天死亡。通过中国疾病预防控制中心对下呼吸道标本进行逆转录聚合酶链反应（RT-PCR）和实时PCR，确诊为甲型流感（H(5)N(1)）。尸检显示支气管充血、广泛实变、浆膜腔积液、弥散性血管内凝血（DIC）和多器官功能衰竭（MOF）。
高致病性甲型禽流感（H(5)N(1)）感染人类是一种致命的传染病。了解甲型禽流感（H(5)N(1)）病毒信息、更加关注流行病学数据以及早期干预对于降低死亡率至关重要。
