Hasan Nazarul, Yusuf Nabiha, Toossi Zahra, Islam Najmul
Department of Biochemistry, Faculty of Medicine, J.N. Medical College, A.M.U., Aligarh 202002, U.P., India.
FEBS Lett. 2006 May 1;580(10):2517-22. doi: 10.1016/j.febslet.2006.03.071. Epub 2006 Apr 7.
Chronic inflammation associated with tumor necrosis factor (TNF)-alpha and reactive oxygen species (ROS) is the hallmark of tuberculosis. Mycobacterium tuberculosis (MTB) directly stimulates human monocytes to secrete TNF-alpha. We show the augmented expression of TNF-alpha mRNA in MTB-infected monocytes by cellular activation and ROS was suppressed by allicin in a dose-dependent manner. Also, allicin enhanced the glutathione peroxidase activity, which correlated inversely with the downregulation of ROS and TNF-alpha in MTB-infected monocytes. Hence, allicin may prove to be a valuable natural antioxidant in combating tuberculosis.
与肿瘤坏死因子（TNF）-α和活性氧（ROS）相关的慢性炎症是结核病的标志。结核分枝杆菌（MTB）直接刺激人类单核细胞分泌TNF-α。我们发现，通过细胞活化，MTB感染的单核细胞中TNF-α mRNA表达增加，而大蒜素以剂量依赖的方式抑制ROS。此外，大蒜素增强了谷胱甘肽过氧化物酶的活性，这与MTB感染的单核细胞中ROS和TNF-α的下调呈负相关。因此，大蒜素可能被证明是对抗结核病的一种有价值的天然抗氧化剂。
