大蒜素对结核分枝杆菌诱导的人单核细胞中活性氧（ROS）和肿瘤坏死因子-α（TNF-α）mRNA表达的抑制作用。
Suppression of Mycobacterium tuberculosis induced reactive oxygen species (ROS) and TNF-alpha mRNA expression in human monocytes by allicin.
作者信息
Hasan Nazarul, Yusuf Nabiha, Toossi Zahra, Islam Najmul
机构信息
Department of Biochemistry, Faculty of Medicine, J.N. Medical College, A.M.U., Aligarh 202002, U.P., India.
出版信息
FEBS Lett. 2006 May 1;580(10):2517-22. doi: 10.1016/j.febslet.2006.03.071. Epub 2006 Apr 7.
Chronic inflammation associated with tumor necrosis factor (TNF)-alpha and reactive oxygen species (ROS) is the hallmark of tuberculosis. Mycobacterium tuberculosis (MTB) directly stimulates human monocytes to secrete TNF-alpha. We show the augmented expression of TNF-alpha mRNA in MTB-infected monocytes by cellular activation and ROS was suppressed by allicin in a dose-dependent manner. Also, allicin enhanced the glutathione peroxidase activity, which correlated inversely with the downregulation of ROS and TNF-alpha in MTB-infected monocytes. Hence, allicin may prove to be a valuable natural antioxidant in combating tuberculosis.
与肿瘤坏死因子（TNF）-α和活性氧（ROS）相关的慢性炎症是结核病的标志。结核分枝杆菌（MTB）直接刺激人类单核细胞分泌TNF-α。我们发现，通过细胞活化，MTB感染的单核细胞中TNF-α mRNA表达增加，而大蒜素以剂量依赖的方式抑制ROS。此外，大蒜素增强了谷胱甘肽过氧化物酶的活性，这与MTB感染的单核细胞中ROS和TNF-α的下调呈负相关。因此，大蒜素可能被证明是对抗结核病的一种有价值的天然抗氧化剂。
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