Savoye Guillaume, Bouin Mickael, Labbé Louis, Mosni Grégory, Morcamp Paola, Denis Philippe, Ducrotté Philippe
Groupe Appareil Digestif Environnement Nutrition, Rouen University Hospital, France.
Scand J Gastroenterol. 2006 May;41(5):536-43. doi: 10.1080/00365520500335175.
To describe the concomitant effects of octreotide and sumatriptan on fundic tone and duodenal phase III activity.
A double-blind study was performed in nine volunteers, studied for 2 h after receiving 50 microg octreotide, 6 mg sumatriptan or placebo. Fundic tone variations were assessed by barostat while antroduodenal motility was studied concomitantly using manometry.
A rapid increase in intrabag volume was observed in all but one subject after both sumatriptan and octreotide administration, while only two subjects exhibited a volume variation after placebo, p<0.01. A significant decrease in the number of phasic contractions was observed after octreotide, while sumatriptan reduced only wave amplitudes (p<0.05). A total of 13 concomitant duodenal phase III-like activities were observed in the duodenum after octreotide, 3 after sumatriptan and 4 after placebo, all followed by spontaneous fundic relaxation with disappearance of phasic contractions, p<0.05. Spontaneous phase III activities were different from phases III-like activities after octreotide in velocity and duration (p<0.05).
Octreotide induced concomitant fundic relaxation, disappearance of phasic contractions and duodenal phase III-like activity. Sumatriptan relaxed the proximal stomach and reduced the amplitude of fundic phasic contractions without affecting concomitant antroduodenal phase III activity.
描述奥曲肽和舒马曲坦对胃底张力和十二指肠Ⅲ期活动的联合作用。
对9名志愿者进行双盲研究，在接受50微克奥曲肽、6毫克舒马曲坦或安慰剂后进行2小时的研究。通过压力测定法评估胃底张力变化，同时使用测压法研究胃十二指肠运动。
在给予舒马曲坦和奥曲肽后，除一名受试者外，其他所有受试者的袋内体积均迅速增加，而给予安慰剂后只有两名受试者出现体积变化，p<0.01。奥曲肽给药后，相性收缩次数显著减少，而舒马曲坦仅降低波幅（p<0.05）。奥曲肽给药后，十二指肠共观察到13次类似十二指肠Ⅲ期的活动，舒马曲坦给药后观察到3次，安慰剂给药后观察到4次，所有这些活动之后均出现胃底自发性松弛，相性收缩消失，p<0.05。自发性Ⅲ期活动在速度和持续时间上与奥曲肽给药后的Ⅲ期样活动不同（p<0.05）。
奥曲肽可引起胃底同时性松弛、相性收缩消失及十二指肠Ⅲ期样活动。舒马曲坦可使胃近端松弛，降低胃底相性收缩幅度，但不影响同时性胃十二指肠Ⅲ期活动。
