Vesta Kimi S, Martina Shaunta' D, Kozlowski Ellen A
Department of Pharmacy, Clinical and Administrative Sciences, College of Pharmacy, University of Oklahoma, Oklahoma City, OK 73190-5040, USA.
Ann Pharmacother. 2006 May;40(5):980-2. doi: 10.1345/aph.1G555. Epub 2006 Apr 25.
To report a case of propofol-induced priapism.
A 17-year-old male receiving propofol for induction of anesthesia during a cardiac ablation procedure developed priapism that required medical intervention and discontinuation of propofol. The priapism developed after a total propofol dose of 550 mg, lasted for 2 hours, and resolved immediately following medical intervention. The following day, the patient underwent a transesophageal echocardiogram and received a total propofol dose of 40 mg throughout the procedure. He again developed priapism, which resolved within one hour without medical intervention.
Priapism experienced by this patient is considered to be drug-induced because of the temporal relationship, recurrence with rechallenge, and dose-response relationship. Using the Naranjo probability scale, we determined that propofol was a highly probable causative agent of priapism in this patient.
Although, as of April 4, 2006, this adverse effect has not been previously reported, there is a strong correlation of propofol to priapism in this patient. Clinicians should be aware of this adverse effect.
报告一例丙泊酚诱发的阴茎异常勃起病例。
一名17岁男性在心脏消融手术中接受丙泊酚诱导麻醉时出现阴茎异常勃起，需要医学干预并停用丙泊酚。阴茎异常勃起在丙泊酚总剂量达550毫克后出现，持续2小时，经医学干预后立即消退。次日，患者接受经食管超声心动图检查，整个过程中丙泊酚总剂量为40毫克。他再次出现阴茎异常勃起，未经医学干预在1小时内消退。
鉴于时间关系、再次用药复发以及剂量反应关系，该患者经历的阴茎异常勃起被认为是药物诱发的。使用Naranjo概率量表，我们确定丙泊酚是该患者阴茎异常勃起的极有可能的致病因素。
尽管截至2006年4月4日，此前尚未报道过这种不良反应，但在该患者中丙泊酚与阴茎异常勃起有很强的相关性。临床医生应意识到这种不良反应。
