Oishi Namiki, Morikubo Soichi, Takamura Yoshihiro, Kubo Eri, Tsuzuki Shosai, Tanimoto Tsuyoshi, Akagi Yoshio
Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Invest Ophthalmol Vis Sci. 2006 May;47(5):2061-4. doi: 10.1167/iovs.05-1042.
To investigate the correlation between adult diabetic cataracts and levels of aldose reductase (AR) in red blood cells (RBCs).
The study involved 337 eyes of 337 patients with diabetes. The extent and severity of lens opacity was assessed according to the Lens Opacities Classification System III (LOCS III). The AR levels within RBCs were determined with an ELISA. The relationship between the AR level in RBCs and the prevalence of nuclear cataract, cortical cataract, and posterior subcapsular cataract in patients with diabetes was examined.
There were no significant alterations in AR level in RBCs in patients with a diabetes duration of < or = 10 years and patients < 60 years of age. In each subgroup, a higher amount of AR levels in RBCs significantly correlated with the prevalence of posterior subcapsular cataracts. A significant association between cortical cataract and AR level in RBCs was also seen in a subgroup of patients younger than 60 years.
AR emerges as an important factor affecting the onset of posterior subcapsular cataracts at the early stages of diabetes mellitus. This raises the possibility that AR inhibitors could play a useful role in treatment of adult diabetic cataract through its inhibition of AR activities.
探讨成年糖尿病性白内障与红细胞中醛糖还原酶（AR）水平之间的相关性。
该研究纳入了337例糖尿病患者的337只眼。根据晶状体混浊分类系统III（LOCS III）评估晶状体混浊的范围和严重程度。采用酶联免疫吸附测定法（ELISA）测定红细胞内的AR水平。研究糖尿病患者红细胞内AR水平与核性白内障、皮质性白内障和后囊下白内障患病率之间的关系。
糖尿病病程≤10年的患者以及年龄<60岁的患者，其红细胞内AR水平无显著变化。在每个亚组中，红细胞内较高水平的AR与后囊下白内障的患病率显著相关。在年龄小于60岁的患者亚组中，也观察到皮质性白内障与红细胞内AR水平之间存在显著关联。
AR是糖尿病早期影响后囊下白内障发病的一个重要因素。这增加了AR抑制剂通过抑制AR活性在成年糖尿病性白内障治疗中发挥有益作用的可能性。
