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目前对糖尿病性白内障发病机制的认识。

Current Approach to the Pathogenesis of Diabetic Cataracts.

机构信息

Department of Ophthalmology and Eye Rehabilitation, Medical University of Bialystok, Waszyngtona 17, 15-274 Bialystok, Poland.

Department of Ophthalmology, Subcarpathian Hospital in Krosno, Korczynska 57, 38-400 Krosno, Poland.

出版信息

Int J Mol Sci. 2023 Mar 28;24(7):6317. doi: 10.3390/ijms24076317.

DOI:10.3390/ijms24076317
PMID:37047290
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10094546/
Abstract

Cataracts remain the first or second leading cause of blindness in all world regions. In the diabetic population, cataracts not only have a 3-5 times higher incidence than in the healthy population but also affect people at a younger age. In patients with type 1 diabetes, cataracts occur on average 20 years earlier than in the non-diabetic population. In addition, the risk of developing cataracts increases with the duration of diabetes and poor metabolic control. A better understanding of the mechanisms leading to the formation of diabetic cataracts enables more effective treatment and a holistic approach to the patient.

摘要

白内障仍然是所有世界区域导致失明的第一或第二大原因。在糖尿病患者中,白内障的发病率不仅比健康人群高 3-5 倍,而且发病年龄也更早。在 1 型糖尿病患者中,白内障的平均发病时间比非糖尿病患者早 20 年。此外,白内障的发病风险随着糖尿病的持续时间和代谢控制的恶化而增加。更好地了解导致糖尿病性白内障形成的机制,可以实现更有效的治疗和对患者的整体治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78a2/10094546/b977e43fde33/ijms-24-06317-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78a2/10094546/3c2c4b3700bd/ijms-24-06317-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78a2/10094546/b977e43fde33/ijms-24-06317-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78a2/10094546/3c2c4b3700bd/ijms-24-06317-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78a2/10094546/b977e43fde33/ijms-24-06317-g002.jpg

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Blocking of SGLT2 to Eliminate NADPH-Induced Oxidative Stress in Lenses of Animals with Fructose-Induced Diabetes Mellitus.
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