Kelesidis Theodore, Mantzoros Christos S
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
Pediatr Endocrinol Rev. 2006 Mar;3(3):239-48.
Leptin is an adipocyte-secreted hormone which plays a key role in energy homeostasis. Recent advances in leptin physiology have revealed that the main role of this hormone in humans is to signal energy availability in energy-deficient states. Interventional studies in leptin deficient children and observational studies in normal girls and boys support a role for leptin as a permissive factor for the initiation of puberty in children. Moreover, recent "proof of concept" studies involving leptin administration to humans further support its critical role in regulating energy homeostasis, neuroendocrine and immune function as well as insulin resistance in states of energy/caloric deprivation. Leptin's potential role in the therapy of several disease states, including hypothalamic amenorrhea, anorexia nervosa and syndromes of insulin resistance is under intensive investigation.
瘦素是一种由脂肪细胞分泌的激素，在能量平衡中起关键作用。瘦素生理学的最新进展表明，这种激素在人类中的主要作用是在能量缺乏状态下传递能量可用性信号。对瘦素缺乏儿童的干预研究以及对正常女孩和男孩的观察性研究支持了瘦素作为儿童青春期启动的许可因子的作用。此外，最近涉及向人类施用瘦素的“概念验证”研究进一步支持了其在能量/热量剥夺状态下调节能量平衡、神经内分泌和免疫功能以及胰岛素抵抗方面的关键作用。瘦素在包括下丘脑性闭经、神经性厌食症和胰岛素抵抗综合征在内的几种疾病状态治疗中的潜在作用正在深入研究中。
