Melis Marcovalerio, Choi Eugene A, Anders Robert, Christiansen Peter, Fichera Alessandro
Department of Surgery, University of Chicago Hospitals, 5841 S. Maryland Avenue, Chicago, IL 60637, USA.
Int J Colorectal Dis. 2007 Feb;22(2):109-14. doi: 10.1007/s00384-006-0089-6. Epub 2006 Apr 26.
Little is known about the synchronous occurrence of gastrointestinal stromal tumors (GISTs) and other gastrointestinal tumors. We present two cases of an invasive colon cancer with a synchronous small-bowel GIST; immunohistochemistry studies were performed to evaluate possible genetic similarities.
This paper reports two cases of synchronous GISTs and colorectal cancer (CRC) with immunohistochemistry analysis of c-Kit expression. This paper is also a review of the existing literature on the association of GISTs and CRC and the role of c-Kit in CRC.
In the last 2 years, we observed two patients with synchronous CRCs and GISTs of the small bowel. The GISTs were incidentally discovered during the work-up for CRCs and excised at the time of the colon resection. Immunohistochemistry study did not reveal an expression of c-Kit in CRCs. Clinical implications of the association between these two neoplasms are described in this paper.
Synchronous CRC and GIST has been more frequently reported. Because of the limited number of cases, we cannot exclude an incidental relationship. The genetic pathways of tumorigenesis appear different for the two neoplasms. Further studies are needed to clarify a possible role of c-Kit in the development of colonic adenocarcinomas.
关于胃肠道间质瘤（GIST）与其他胃肠道肿瘤的同步发生情况，人们了解甚少。我们报告了两例侵袭性结肠癌合并同步发生的小肠GIST病例；进行了免疫组织化学研究以评估可能的基因相似性。
本文报告了两例同步发生的GIST与结直肠癌（CRC）病例，并对c-Kit表达进行了免疫组织化学分析。本文也是对关于GIST与CRC关联以及c-Kit在CRC中的作用的现有文献的综述。
在过去两年中，我们观察到两名患有同步性CRC和小肠GIST的患者。这些GIST在CRC的检查过程中偶然发现，并在结肠切除时切除。免疫组织化学研究未发现CRC中有c-Kit表达。本文描述了这两种肿瘤之间关联的临床意义。
同步性CRC和GIST的报道越来越多。由于病例数量有限，我们不能排除偶然关系。这两种肿瘤的肿瘤发生遗传途径似乎不同。需要进一步研究以阐明c-Kit在结肠腺癌发生中的可能作用。
