Department of Surgical Pathology, Saint Savvas Anticancer Hospital, Athens, Greece.
In Vivo. 2010 Jan-Feb;24(1):109-15.
Gastrointestinal stromal tumors (GISTs) are common mesenchymal neoplasms of the digestive tract and may occasionally arise within the abdomen without gastrointestinal tract connection. GISTs have recently attracted widespread interest because of the development of effective targeted molecular agents against it. While synchronous occurrence of a GIST with a tumor of different histogenesis was thought to be very rare, it is now apparent that they are more common than previously believed.
We report our experience with GISTs and also six cases of GIST coexisting with other primary neoplasms. Using immunohistochemistry and mutational analysis, a possible correlation was investigated. A review of the literature was also conducted.
There were no significant differences in the immumohistochemical and molecular profile between single GISTs and GISTs coexisting with other tumors, nor was there any mutational correlation between GISTs and the coexistent tumors of different histogenesis regarding KIT and PDGFRA genes.
Further molecular biology studies are required in order to investigate thoroughly the simultaneous development of tumors with different histotypes.
胃肠道间质瘤（GIST）是消化道常见的间叶性肿瘤，偶尔也会在没有消化道联系的情况下出现在腹部。由于针对 GIST 的有效靶向分子药物的发展，GIST 最近引起了广泛关注。虽然同时发生的 GIST 与不同组织发生的肿瘤被认为非常罕见，但现在显然比以前认为的更常见。
我们报告了我们在 GIST 方面的经验，以及六例 GIST 与其他原发性肿瘤并存的病例。使用免疫组织化学和突变分析，研究了可能的相关性。还进行了文献复习。
单一 GIST 和与其他肿瘤并存的 GIST 在免疫组织化学和分子特征方面没有显著差异，GIST 与不同组织发生的共存肿瘤之间在 KIT 和 PDGFRA 基因方面也没有突变相关性。
需要进一步的分子生物学研究，以彻底研究不同组织类型肿瘤的同时发生。
