Guzzetti S, Dassi S, Pecis M, Casati R, Masu A M, Longoni P, Tinelli M, Cerutti S, Pagani M, Malliani A
Istituto Ricerche Cardiovascolari, Ospedale L. Saccó, Università Milano, Italy.
J Hypertens. 1991 Sep;9(9):831-8. doi: 10.1097/00004872-199109000-00010.
We addressed the problem of the circadian changes in neural control of heart period in ambulant hypertensive subjects. A running spectral analysis of R-R variability from Holter tapes provided markers of sympathetic, i.e. low-frequency component (LF) almost equal to 0.10 Hz, and vagal, i.e. high-frequency component (HF) almost equal to 0.25 Hz, controlling activities for the 24-h period of the recording. Significant circadian differences were observed in LF between the two groups of subjects: during night-time rest (0300-0400 h), LF was greater in hypertensives than in normotensives (56 +/- 2 and 48 +/- 2 nu, respectively; P less than 0.05). Furthermore, the difference between daytime and night-time LF values was progressively reduced with increasing severity of the hypertensive state, as assessed by resting arterial pressure levels. Spectral analysis of R-R variability suggests that essential hypertension may be characterized by a reduced day-night oscillation in sympathetic activity than can be quantified non-invasively using this approach.
我们研究了动态高血压患者心脏周期神经控制的昼夜变化问题。通过对动态心电图磁带记录的R-R间期变异性进行频谱分析，得到了交感神经控制活动（低频成分，即LF，约等于0.10Hz）和迷走神经控制活动（高频成分，即HF，约等于0.25Hz）在记录的24小时内的指标。两组受试者的LF存在显著的昼夜差异：夜间休息时（03:00 - 04:00），高血压患者的LF高于正常血压者（分别为56±2和48±2nu；P<0.05）。此外，根据静息动脉压水平评估，随着高血压状态严重程度的增加，白天和夜间LF值之间的差异逐渐减小。R-R间期变异性的频谱分析表明，原发性高血压的特征可能是交感神经活动的昼夜振荡减弱，这种减弱可以通过这种方法进行无创量化。
