青少年原发性高血压的心脏自主神经控制。
Cardiac autonomic control in adolescents with primary hypertension.
机构信息
Department of Paediatrics, Jessenius School of Medicine, Comenius University, Martin, Slovakia.
出版信息
Eur J Med Res. 2009 Dec 7;14 Suppl 4(Suppl 4):101-3. doi: 10.1186/2047-783x-14-s4-101.
BACKGROUND
Impairment in cardiovascular autonomic regulation participates in the onset and maintenance of primary hypertension.
OBJECTIVE
The aim of the present study was to evaluate cardiac autonomic control using long-term heart rate variability (HRV) analysis in adolescents with primary hypertension.
SUBJECTS AND METHODS
Twenty two adolescent patients with primary hypertension (5 girls/17 boys) aged 14-19 years and 22 healthy subjects matched for age and gender were enrolled. Two periods from 24-hour ECG recording were evaluated by HRV analysis: awake state and sleep. HRV analysis included spectral power in low frequency band (LF), in high frequency band (HF), and LF/HF ratio. -
RESULTS
In awake state, adolescents with primary hypertension had lower HF and higher LF and LF/HF ratio. During sleep, HF was lower and LF/HF ratio was higher in patients with primary hypertension.
CONCLUSIONS
A combination of sympathetic predominance and reduced vagal activity might represent a potential link between psychosocial factors and primary hypertension, associated with increased cardiovascular morbidity.
背景
心血管自主调节功能障碍参与原发性高血压的发生和维持。
目的
本研究旨在通过对原发性高血压青少年进行长期心率变异性（HRV）分析，评估心脏自主神经控制情况。
受试者和方法
纳入年龄在 14-19 岁的 22 例原发性高血压青少年患者（女 5 例/男 17 例）和 22 例年龄和性别相匹配的健康受试者。通过 HRV 分析评估 24 小时心电图记录的两个时间段：清醒状态和睡眠状态。HRV 分析包括低频带（LF）、高频带（HF）和 LF/HF 比值的频谱功率。
结果
在清醒状态下，原发性高血压青少年的 HF 较低，LF 和 LF/HF 比值较高。在睡眠期间，原发性高血压患者的 HF 较低，LF/HF 比值较高。
结论
交感神经优势和迷走神经活性降低的结合可能是心理社会因素与原发性高血压之间的潜在联系，与心血管发病率增加有关。
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